INSERM, UMR1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université de Lille, Centre Hosp. Univ Lille, Institut Pasteur de Lille, France.
Faculty of Medicine, Department of Epidemiology and Public Health, University of Strasbourg, France.
Eur J Prev Cardiol. 2020 Jul;27(11):1178-1186. doi: 10.1177/2047487319899193. Epub 2020 Feb 26.
Over the past few decades decreases in coronary heart disease morbidity and mortality rates have been observed throughout the western world. We sought to determine whether the acute coronary event rates had decreased between 2006 and 2014 among French adults, and whether there were sex and age-specific differences.
We examined the French MONICA population-based registries monitoring the Lille urban area in northern France, the Bas-Rhin county in north-eastern France and the Haute Garonne county in south-western France. All acute coronary events among men and women aged 35-74 were collected.
Over the study period, the age-standardised attack rates decreased in both men (annual percentage change -1.5%, = 0.0006) and women (annual percentage change -2.1%, = 0.002). Also, the age-standardised incidence rates decreased in both men (annual percentage change -0.9%, = 0.03) and women (annual percentage change -1.8%, = 0.002) due to decreases in the 65-74 year age group. In men, age-standardised mortality rates decreased by 3.5% per year ( = 0.0004), especially in the 55-64 and 65-74 year age groups. In women, these rates decreased by 4.3% per year ( = 0.0009), particularly in the 35-44 and 65-74 year age groups. We also observed significant decreases in case fatality among both men (annual percentage change -1.7%, < 0.0001) and women (annual percentage change -1.9%, = 0.009).
Downward trends in acute coronary event attack, incidence and mortality rates were observed between 2006 and 2014 in men and women. This effect was age dependent and was primarily due to decreases in the 65-74 year age group. There were no substantial declines in the younger age groups except for mortality in young women. Prevention measures still need to be strengthened, particularly in young adults.
在过去几十年中，西方世界的冠心病发病率和死亡率都有所下降。我们旨在确定 2006 年至 2014 年间法国成年人的急性冠状动脉事件发生率是否有所下降，以及是否存在性别和年龄特异性差异。
我们研究了监测法国北部里尔市区、东北部下莱茵省和西南部上加龙省的法国 MONICA 基于人群的登记处。收集了所有年龄在 35-74 岁的男性和女性的急性冠状动脉事件。
在研究期间，男性（年百分比变化-1.5%， = 0.0006）和女性（年百分比变化-2.1%， = 0.002）的年龄标准化发病率均呈下降趋势。此外，由于 65-74 岁年龄组的发病率下降，男性（年百分比变化-0.9%， = 0.03）和女性（年百分比变化-1.8%， = 0.002）的年龄标准化发生率也有所下降。在男性中，年龄标准化死亡率每年下降 3.5%（ = 0.0004），尤其是在 55-64 岁和 65-74 岁年龄组。在女性中，这些比率每年下降 4.3%（ = 0.0009），尤其是在 35-44 岁和 65-74 岁年龄组。我们还观察到男性（年百分比变化-1.7%， < 0.0001）和女性（年百分比变化-1.9%， = 0.009）的病死率均显著下降。
2006 年至 2014 年间，男性和女性的急性冠状动脉事件发病率、发生率和死亡率呈下降趋势。这种影响与年龄有关，主要是由于 65-74 岁年龄组的发病率下降。除了年轻女性的死亡率外，年轻年龄组的下降幅度不大。仍需加强预防措施，特别是在年轻成年人中。
