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消除丙型肝炎:需要采取公共卫生应对措施。

Eradicating hepatitis C: The need for a public health response.

机构信息

a Australian Research Centre in Sex, Health and Society , La Trobe University , Melbourne , Australia.

出版信息

Glob Public Health. 2018 Sep;13(9):1254-1264. doi: 10.1080/17441692.2017.1342851. Epub 2017 Jun 22.

Abstract

Hepatitis C is a global public health issue affecting 150-170 million people worldwide, and over 227,000 Australians with an increasing morbidity resulting from the infection. The Australian Government funded access through the national health scheme to Direct Acting Antiviral (DAA) medication for all people with hepatitis C, regardless of disease staging or mode of transmission to eradicate hepatitis C in Australia. The availability of these drugs not only alters the end result of hepatitis C treatment from that of sustained viral response to cure, but necessitates a refocusing of the public health response to hepatitis C. This project, conducted prior to this funding announcement, interviewed key stakeholders in Australia to investigate the potential impact of DAAs on individuals with hepatitis C and their public health implications. The findings include that while DAAs are revolutionary, there remains essential barriers to their uptake including stigma and discrimination, and a lack of attention to the systematic implementation of the cure.

摘要

丙型肝炎是一个全球性的公共卫生问题,影响到全球 1.5 亿至 1.7 亿人,澳大利亚有超过 22.7 万人因感染而发病率不断上升。澳大利亚政府通过国家卫生计划为所有丙型肝炎患者提供直接作用抗病毒药物(DAA)治疗的资金,无论疾病分期或传播途径如何,旨在在澳大利亚消除丙型肝炎。这些药物的出现不仅改变了丙型肝炎治疗的最终结果,从持续病毒应答转变为治愈,而且需要重新关注丙型肝炎的公共卫生应对措施。本项目在该资金宣布之前进行,对澳大利亚的主要利益相关者进行了访谈,以调查 DAA 对丙型肝炎患者及其公共卫生影响的潜在影响。研究结果表明,尽管 DAA 具有革命性意义,但仍存在一些基本的障碍,包括耻辱感和歧视,以及对治愈方案的系统实施缺乏关注。

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