纳曲酮对阿尔茨海默型老年痴呆症的影响。
Effect of naltrexone on senile dementia of the Alzheimer type.
作者信息
Hyman B T, Eslinger P J, Damasio A R
出版信息
J Neurol Neurosurg Psychiatry. 1985 Nov;48(11):1169-71. doi: 10.1136/jnnp.48.11.1169.
Abstract
Some reports have suggested that naloxone, a short-acting opiate receptor blocker given intravenously, has a beneficial effect on the symptoms of senile dementia of the Alzheimer type. We have performed a double-blind, crossover trial of naltrexone, an orally active, long acting opiate antagonist, in 17 Alzheimer-type dementia patients. None showed any improvement in assessments of day-to-day living skills or on a battery of neuropsychological tests. No side effects were noted. In the dosage used, naltrexone appears not to be useful in Alzheimer-type dementia.
摘要
一些报告表明，静脉注射的短效阿片受体阻滞剂纳洛酮对阿尔茨海默型老年痴呆症的症状有有益影响。我们对17名阿尔茨海默型痴呆症患者进行了一项关于口服活性长效阿片拮抗剂纳曲酮的双盲交叉试验。在日常生活技能评估或一系列神经心理学测试中，没有人表现出任何改善。未观察到副作用。在所使用的剂量下，纳曲酮似乎对阿尔茨海默型痴呆症没有用处。
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