Al Saikhan Lamia, Park Chloe, Hardy Rebecca, Hughes Alun
Institute of Cardiovascular Science, School of Life and Medical Sciences, University College London, London, UK.
Department of Cardiac Technology, College of Applied Medial Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
BMJ Open. 2018 Jul 16;8(7):e023346. doi: 10.1136/bmjopen-2018-023346.
Left ventricular (LV) strain by speckle-tracking echocardiography (STE) is a comparatively new prognostic marker. Meta-analyses relating LV strain by STE to outcomes have been conducted in selected patient-based populations with established or suspected cardiovascular (CV) diseases. However, the evidence related to population-based studies of community-dwelling individuals is uncertain. The aim of this study is to provide a comprehensive systematic review and analysis of the current available literature regarding LV strain by STE as a predictor of adverse outcomes in population-based studies.
Thesaurus and text-word searching will be used to search two online databases (MEDLINE and EMBASE) and additional sources will be identified from citation metrics and reference lists' search. Dual search results' screening, data extraction and quality assessment will be performed. Cohort studies of community/population-based samples who have had STE and followed up longitudinally for mortal and morbid events, and published in English and peer-reviewed journals will be included. Primary outcome will be all-cause mortality whereas secondary outcomes will be composite cardiac and CV end points. Risk of bias will be assessed using Newcastle-Ottawa Quality Assessment Scale of cohort studies that will be modified as appropriate. Any arising discrepancies will be discussed and resolved through consensus.
Ethical approval is not required as this is a protocol for a systematic review. The findings of this study will be presented at scientific conferences and published in a peer-reviewed journal. Any amendments to the protocol will be documented and updated in the PROSPERO registry.
CRD42018090302.
斑点追踪超声心动图（STE）测量的左心室（LV）应变是一种相对较新的预后标志物。在选定的患有已确诊或疑似心血管（CV）疾病的患者群体中，已经进行了关于STE测量的LV应变与预后关系的荟萃分析。然而，与基于社区人群的研究相关的证据尚不确定。本研究的目的是对目前关于STE测量的LV应变作为基于人群研究中不良结局预测指标的现有文献进行全面的系统评价和分析。
将使用主题词表和文本词搜索来检索两个在线数据库（MEDLINE和EMBASE），并从引用指标和参考文献列表搜索中识别其他来源。将进行双检索结果筛选、数据提取和质量评估。纳入对接受过STE检查并对死亡和发病事件进行纵向随访的社区/人群样本进行的队列研究，这些研究需以英文发表并经过同行评审。主要结局将是全因死亡率，次要结局将是心脏和CV复合终点。将使用队列研究的纽卡斯尔-渥太华质量评估量表评估偏倚风险，并将根据需要进行适当修改。出现的任何差异将通过讨论并达成共识来解决。
由于这是一项系统评价方案，无需伦理批准。本研究的结果将在科学会议上展示，并发表在同行评审期刊上。对方案的任何修改将记录在案并在PROSPERO注册中心更新。
PROSPERO注册号：CRD42018090302。
