Fernandez Dawn M, Clemente Jose C, Giannarelli Chiara
Department of Medicine, Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Physiol. 2018 Jun 29;9:763. doi: 10.3389/fphys.2018.00763. eCollection 2018.
Cardiovascular health is a primary research focus, as it is a leading contributor to mortality and morbidity worldwide, and is prohibitively costly for healthcare. Atherosclerosis, the main driver of cardiovascular disease, is now recognized as an inflammatory disorder. Physical activity (PA) may have a more important role in cardiovascular health than previously expected. This review overviews the contribution of PA to cardiovascular health, the inflammatory role of atherosclerosis, and the emerging evidence of the microbiome as a regulator of inflammation.
心血管健康是主要的研究重点，因为它是全球死亡率和发病率的主要促成因素，且医疗成本高昂。动脉粥样硬化是心血管疾病的主要驱动因素，如今被认为是一种炎症性疾病。体育活动（PA）在心血管健康中的作用可能比之前预期的更为重要。本综述概述了体育活动对心血管健康的贡献、动脉粥样硬化的炎症作用，以及微生物群作为炎症调节因子的新证据。
