Mukoyama Nobuaki, Suzuki Hidenori, Hanai Nobuhiro, Sone Michihiko, Hasegawa Yasuhisa
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Department of Head and Neck Surgery, Aichi Cancer Center Hospital, Nagoya, Aichi 464-8681, Japan.
Oncol Lett. 2018 Aug;16(2):2471-2477. doi: 10.3892/ol.2018.8951. Epub 2018 Jun 12.
The present study examined whether the pathological tumor volume (PTV) was correlated with the survival outcomes in patients with oral squamous cell carcinoma (SCC) and clinical lymph node metastasis. Forty-seven patients who underwent radical surgery without preoperative treatment were enrolled. The PTV of the primary tumor, which was surgically resected without preoperative treatment, was calculated based on the diameters in three dimensions. A survival analysis was performed using a Cox proportional hazards model. A PTV of ≥18 cm was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01) in a univariate analysis. A multivariate analysis with adjustment for the pathological stage (stage I-II/III-IV), primary site (tongue/others) and positive surgical margin and/or extracapsular extension (absent/present) showed that a PTV of ≥18 cm was significantly correlated with shorter overall survival (P<0.01) and local recurrence-free survival (P<0.01). The present findings suggested that PTV in oral SCC provides a prognostic parameter that may predict shorter or longer overall and local recurrence-free survival.
本研究探讨了口腔鳞状细胞癌（SCC）伴临床淋巴结转移患者的病理肿瘤体积（PTV）与生存结局是否相关。纳入了47例未接受术前治疗而行根治性手术的患者。对未接受术前治疗而手术切除的原发肿瘤的PTV，根据三维直径进行计算。采用Cox比例风险模型进行生存分析。单因素分析显示，PTV≥18 cm与总生存期缩短（P<0.01）和无局部复发生存期缩短（P<0.01）显著相关。多因素分析校正了病理分期（I-II期/III-IV期）、原发部位（舌部/其他部位）以及手术切缘阳性和/或包膜外侵犯（无/有）后，显示PTV≥18 cm与总生存期缩短（P<0.01）和无局部复发生存期缩短（P<0.01）显著相关。本研究结果提示，口腔SCC中的PTV可作为一个预后参数，可能预测总生存期和无局部复发生存期的长短。
