Hu H, Cheng K-L, Xu X-Q, Wu F-Y, Tyan Y-S, Tsai C-H, Shen C-Y
From the Department of Radiology (H.H., X.-Q.X., F.-Y.W.), First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Departments of Medical Imaging (K.-L.C., Y.-S.T., C.-Y.S.) School of Medical Imaging and Radiological Sciences (K.-L.C., Y.-S.T., C.-Y.S.) Department of Veterinary Medicine (K.-L.C.), National Chung Hsing University, Taichung, Taiwan.
AJNR Am J Neuroradiol. 2015 Jul;36(7):1338-42. doi: 10.3174/ajnr.A4278. Epub 2015 Apr 2.
Several studies indicated that tumor thickness or tumor volume might be helpful predictors for the prognosis of oral tongue squamous cell carcinoma. Our aim was to compare the value of tumor thickness versus tumor volume measurement based on preoperative MR imaging in predicting the prognosis of oral tongue squamous cell carcinoma, especially focusing on lymph node metastases and local recurrence.
Clinical, pathologic, and imaging data of patients with 46 oral tongue squamous cell carcinomas were retrospectively studied. Logistic regression analysis was used to evaluate the prognostic value of tumor thickness and tumor volume based on MR imaging. Receiver operating characteristic analysis was applied for the optimal cutoff value for the identified risk variable for prognosis.
A higher intraclass correlation coefficient was achieved for the measurement of tumor thickness compared with tumor volume (0.990 versus 0.972). Multivariate analysis showed that tumor thickness was a significant predictor of lymph node metastases (P = .024), while tumor volume was not a significant predictor of either lymph node metastases or local recurrence (P > .05). Receiver operating characteristic results indicated that setting a tumor thickness of 8.5 mm as a cutoff value could achieve the optimal diagnostic efficiency for predicting lymph node metastases (area under the curve, 0.753; sensitivity, 0.889; specificity, 0.536).
Tumor thickness based on preoperative MR imaging was useful in predicting the prognosis of oral tongue squamous cell carcinoma, especially lymph node metastases, in our patient population, while tumor volume was not.
多项研究表明，肿瘤厚度或肿瘤体积可能是口腔舌鳞状细胞癌预后的有用预测指标。我们的目的是比较基于术前磁共振成像测量的肿瘤厚度与肿瘤体积在预测口腔舌鳞状细胞癌预后方面的价值，尤其关注淋巴结转移和局部复发情况。
对46例口腔舌鳞状细胞癌患者的临床、病理和影像数据进行回顾性研究。采用逻辑回归分析基于磁共振成像评估肿瘤厚度和肿瘤体积的预后价值。应用受试者工作特征分析确定预后风险变量的最佳截断值。
与肿瘤体积测量相比，肿瘤厚度测量的组内相关系数更高（0.990对0.972）。多因素分析显示，肿瘤厚度是淋巴结转移的显著预测指标（P = 0.024），而肿瘤体积既不是淋巴结转移也不是局部复发的显著预测指标（P > 0.05）。受试者工作特征分析结果表明，将肿瘤厚度8.5 mm设定为截断值可在预测淋巴结转移方面实现最佳诊断效率（曲线下面积，0.753；敏感度，0.889；特异度，0.536）。
在我们的患者群体中，基于术前磁共振成像的肿瘤厚度有助于预测口腔舌鳞状细胞癌的预后，尤其是淋巴结转移情况，而肿瘤体积则不然。
