中国深圳健康儿童上呼吸道的微生物群落组成因呼吸道部位和年龄而异。
Microbiota Composition in Upper Respiratory Tracts of Healthy Children in Shenzhen, China, Differed with Respiratory Sites and Ages.
机构信息
Department of Respiratory Diseases, Shenzhen Children's Hospital, Shenzhen 518026, China.
Department of Computer Science, City University of Hong Kong, Kowloon Tong 999077, Hong Kong.
出版信息
Biomed Res Int. 2018 Jun 14;2018:6515670. doi: 10.1155/2018/6515670. eCollection 2018.
The upper respiratory tract (URT) is home to various microbial commensals, which function as competitors to pathogens and help train the immune system. However, few studies have reported the normal microbiota carriage in the URT of healthy Chinese children. In this study, we performed a 16S rDNA gene sequencing analysis of 83 anterior nares (ANs), 60 nasopharynx (NP), and 97 oropharynx (OP) samples from 98 healthy children in Shenzhen, China (≤12 years of age). The microbiota in ANs and NP is the same at different ages and typical species in these sites include , , , , and . By contrast, the OP is primarily colonized by , , , , , , and . and keep low abundance in OP microbiota of children 1 year old, whereas , , , and amass significantly in individuals 1 year old. This work furnishes an important reference for understanding microbial dysbiosis in the URT of Chinese paediatric patients.
上呼吸道（URT）是各种微生物共生体的家园，它们作为病原体的竞争者，有助于训练免疫系统。然而，很少有研究报道过健康中国儿童 URT 中的正常微生物群携带情况。在这项研究中，我们对 98 名来自中国深圳（≤12 岁）的健康儿童的 83 个前鼻（AN）、60 个鼻咽（NP）和 97 个口咽（OP）样本进行了 16S rDNA 基因测序分析。AN 和 NP 中的微生物群在不同年龄时是相同的，这些部位的典型物种包括、、、、和。相比之下，OP 主要由、、、、、、和定植。1 岁儿童的 OP 微生物群中 和 的丰度较低，而 1 岁时个体中 、 、 和 的丰度显著增加。这项工作为了解中国儿科患者 URT 中的微生物失调提供了重要参考。
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