Osborne Brittany F, Turano Alexandra, Schwarz Jaclyn M
University of Delaware, Department of Psychological and Brain Sciences, 108 Wolf Hall, Newark, DE, 19716, USA.
Curr Opin Behav Sci. 2018 Oct;23:118-123. doi: 10.1016/j.cobeha.2018.05.007.
While sex differences in the peripheral immune response have been studied extensively, sex differences in the response, including glial activation and associated cytokine production in the brain, is a recently emerging field. Advances in our understanding of sex differences in the neuroimmune response have important implications for understanding how neural circuits are shaped during early brain development, how activation of the immune system may impact cognitive function and behavior, and how inflammation may be associated with the risk of mental health disorders that have strong sex-biases. The goal of this mini review is to highlight recent work in the field of sex differences in neuroimmune function, with a particular focus on how microglia function is influenced by age and sex hormone exposure.
虽然外周免疫反应中的性别差异已得到广泛研究，但大脑中的免疫反应，包括神经胶质细胞激活和相关细胞因子产生方面的性别差异，却是一个新兴领域。我们对神经免疫反应中性别差异理解的进展，对于理解神经回路在大脑早期发育过程中如何形成、免疫系统激活如何影响认知功能和行为，以及炎症如何与具有强烈性别倾向的心理健康障碍风险相关联，都具有重要意义。本综述的目的是突出神经免疫功能性别差异领域的最新研究成果，特别关注小胶质细胞功能如何受到年龄和性激素暴露的影响。
