Szeged, Csongrád, Hungary; Department of Obstetrics and Gynecology, University of Szeged, Faculty of Medicine, Szeged, Hungary.
Szeged, Csongrád, Hungary; Department of Medical Physics and Informatics, University of Szeged, Faculty of Medicine, Szeged, Hungary.
Eur J Obstet Gynecol Reprod Biol. 2018 Sep;228:225-231. doi: 10.1016/j.ejogrb.2018.05.040. Epub 2018 Jun 1.
We aimed to investigate and compare placental vascularization indices between monochorionic-diamniotic, dichorionic-diamniotic normal twin pregnancies, and normal singular pregnancies. We hypothesized that there is correlation between placental three-dimensional power Doppler vascularization indices and birth weight in case of twin pregnancies, and that normal singular pregnancies have higher placental vascularization indices than normal twin pregnancies.
Placental three-dimensional power Doppler vascularization indices, such as vascularization index, flow index, and vascularization-flow index were measured in monochorionic-diamniotic (N = 15) and dichorionic-diamniotic (N = 36) normal twin pregnancies, and in normal singular (N = 109) pregnancies. Correlations were analyzed between vascularization indices, and birth weight, APGAR score, umbilical pH, umbilical venous bicarbonate, lactate, and base excess.
Vascularization indices and birth weight were significantly (p < 0.01) higher in normal singular gestations (vascularization index = 10.36, flow index = 46.08, vascularization-flow index = 4.08, average birth weight = 3377 g at 38.2 weeks average gestational age) compared to monochorionic-diamniotic and dichorionic-diamniotic normal twin pregnancies. No significant differences were found in vascularization indices between monochorionic-diamniotic and dichorionic-diamniotic normal twins. There were no significant differences in APGAR score, umbilical pH, umbilical venous bicarbonate, lactate, and base excess between groups examined (p < 0.01). We found strong linear correlations between placental vascularization indices and birth weight in both twin groups.
Placental three-dimensional power Doppler vascularization indices seem appropriate for predicting birth weight in monochorionic-diamniotic and dichorionic-diamniotic normal twin pregnancies. Our pilot study revealed reference values for vascularization indices in case of twin pregnancies examined.
我们旨在研究和比较单绒毛膜-双羊膜、双绒毛膜-双羊膜正常双胎妊娠与正常单胎妊娠之间胎盘血管化指数的差异。我们假设在双胎妊娠中，胎盘三维能量多普勒血管化指数与出生体重之间存在相关性，并且正常单胎妊娠的胎盘血管化指数高于正常双胎妊娠。
测量单绒毛膜-双羊膜（N=15）和双绒毛膜-双羊膜（N=36）正常双胎妊娠以及正常单胎（N=109）妊娠的胎盘三维能量多普勒血管化指数，如血管化指数、血流指数和血管化-血流指数。分析血管化指数与出生体重、新生儿阿普加评分、脐动脉 pH 值、脐静脉碳酸氢盐、乳酸和碱剩余之间的相关性。
正常单胎妊娠的血管化指数和出生体重显著高于单绒毛膜-双羊膜和双绒毛膜-双羊膜正常双胎妊娠（血管化指数=10.36，血流指数=46.08，血管化-血流指数=4.08，平均出生体重=3377g，平均孕龄 38.2 周）。单绒毛膜-双羊膜和双绒毛膜-双羊膜正常双胎妊娠之间的血管化指数无显著差异。各组间新生儿阿普加评分、脐动脉 pH 值、脐静脉碳酸氢盐、乳酸和碱剩余无显著差异（p<0.01）。我们发现两组双胎妊娠的胎盘血管化指数与出生体重之间存在强线性相关性。
胎盘三维能量多普勒血管化指数似乎可用于预测单绒毛膜-双羊膜和双绒毛膜-双羊膜正常双胎妊娠的出生体重。我们的初步研究为双胎妊娠的血管化指数提供了参考值。
