EGFR-ERK 信号通路中的多米诺效应。
The Domino Effect in EGFR-ERK Signaling.
机构信息
Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel.
Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel.
出版信息
Dev Cell. 2018 Jul 16;46(2):128-130. doi: 10.1016/j.devcel.2018.06.021.
A gradient of EGFR-ERK signaling has been classically implicated in various developmental processes. In this issue of Developmental Cell, Ogura et al. (2018) show that in the Drosophila tracheal placode, EGFR-ERK signaling propagates via a cell-by-cell relay mechanism rather than a gradient, and this sequential ERK activation controls proper placode invagination.
EGFR-ERK 信号的梯度在各种发育过程中具有经典意义。在本期《发育细胞》中，Ogura 等人（2018）表明，在果蝇气管基板中，EGFR-ERK 信号通过细胞间的接力机制而不是梯度传递，并且这种顺序 ERK 激活控制着正确的基板内陷。
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