基于图像的低剂量 CT 图像模拟提示，13mAs 120kV 适用于无综合征性颅缝早闭的诊断，无需使用迭代重建算法。
Image based simulation of the low dose computed tomography images suggests 13 mAs 120 kV suitability for non-syndromic craniosynostosis diagnosis without iterative reconstruction algorithms.
机构信息
Department of Radiology, Childrens Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania; Department of Radiology, Nuclear Medicine and Medical Physics, Institute of Biomedical Sciences of the Faculty of Medicine of Vilnius University, Vilnius, Lithuania.
Medical Physics Department, National Cancer Institute, Vilnius, Lithuania.
出版信息
Eur J Radiol. 2018 Aug;105:168-174. doi: 10.1016/j.ejrad.2018.06.005. Epub 2018 Jun 12.
OBJECTIVES
The aim of this study was to simulate low dose paediatric head CT images with different noise levels corresponding to various tube current time product values and assess simulated image suitability in non-syndromic craniosynostosis diagnostics.
METHOD
29 paediatric patients who underwent head CT examinations for cranial deformity were enrolled in the study. The low dose CT images, corresponding to 120 kV and 120 mAs, 100 mAs, 80 mAs, 50 mAs and 13 mAs settings, were synthesised by adding noise to original data. Three researchers evaluated suitability for diagnostics of original and simulated images by using questionnaire assessing image suitability.
RESULT
174 separate cases (containing 1 axial and 1 3D image) were evaluated. Percentage of images evaluated as suitable for diagnosis were 98.9% on original images, 100% on 120 mAs, 100% on 100 mAs, 97.1% on 80 mAs, 96.6% on 50 mAs and 96% on 13 mAs.
CONCLUSIONS
Images registered with 120 kV 13 mAs can be used to diagnose non-syndromic craniosynostosis with statistically same accuracy as with standard protocol and correspond to decrease of effective dose from 4.98 mSv to 0.33 mSv (median values).
目的
本研究旨在模拟不同管电流时间乘积值对应的不同噪声水平的小儿头部 CT 图像，并评估模拟图像在非综合征性颅缝早闭诊断中的适用性。
方法
本研究纳入了 29 例因颅面畸形而行头部 CT 检查的儿科患者。通过向原始数据添加噪声，合成了低剂量 CT 图像，对应 120 kV 和 120 mAs、100 mAs、80 mAs、50 mAs 和 13 mAs 设置。三位研究人员通过评估图像诊断适宜性的问卷评估原始和模拟图像的诊断适宜性。
结果
评估了 174 个独立病例（包含 1 个轴向和 1 个 3D 图像）。原始图像中诊断适宜的图像比例为 98.9%，120 mAs 为 100%，100 mAs 为 100%，80 mAs 为 97.1%，50 mAs 为 96.6%，13 mAs 为 96%。
结论
使用 120 kV 13 mAs 注册的图像可以以与标准方案相同的统计学准确性来诊断非综合征性颅缝早闭，并将有效剂量从 4.98 mSv 降低至 0.33 mSv（中位数）。
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