Lo Presti C, Blaise A, Maestracci M, Larue M
Service pharmacie, centre hospitalier de Salon-de-Provence, 13300 Salon-de-Provence, France.
Service pneumologie, centre hospitalier de Salon-de-Provence, 13300 Salon-de-Provence, France.
Rev Pneumol Clin. 2018 Dec;74(6):458-466. doi: 10.1016/j.pneumo.2018.06.001. Epub 2018 Jul 17.
Fluoroquinolones (FQ) are antibiotics which favour the emergence of resistance and remain widely prescribed in the French hospital environment. A focus of prescription recommendation was published by the French Infectious Diseases Society (SPILF) in 2015 in order to preserve their use. The pneumology-oriented medical service of Salon de Provence's hospital had high FQ consumption for the year 2015; thus a relevant assessment of prescriptions was carried out.
This retrospective study was conducted between January 1 and December 31, 2015 and concerned patients who received at least one FQ administration during their hospitalization.
Thirty-eight per cent of the prescriptions were justified, 37 % were inappropriate and 25 % unjustified. The majority of unjustified prescriptions were for lung infections. Only 35 % of the patients received bacteriological documentation and 53 % of the prescriptions were reassessed at 48-72hours. Twenty-two per cent of the justified prescriptions showed non-conformities concerning the duration of prescriptions, the dosage or an association with another antibiotic.
The diffusion of these results, combined with the implementation of corrective actions, should make it possible to improve the relevance of the FQ prescription.
氟喹诺酮类药物(FQ)是一类容易导致耐药性产生的抗生素,在法国医院环境中仍被广泛使用。为了合理使用这类药物,法国传染病协会(SPILF)于2015年发布了一份处方推荐要点。普罗旺斯地区沙龙市医院的呼吸科在2015年对FQ的消耗量很大,因此对其处方进行了相关评估。
这项回顾性研究于2015年1月1日至12月31日进行,研究对象为住院期间至少接受过一次FQ治疗的患者。
38%的处方是合理的,37%是不恰当的,25%是不合理的。大多数不合理处方用于肺部感染。只有35%的患者有细菌学记录,53%的处方在48至72小时后被重新评估。22%的合理处方在处方时长、剂量或与其他抗生素联合使用方面存在不符合规定的情况。
传播这些结果,并结合采取纠正措施,应该能够提高FQ处方的合理性。