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Oncolytic Virotherapy: Single Cycle Cures or Repeat Treatments? (Repeat Dosing Is Crucial!).

作者信息

Melcher Alan

机构信息

Institute of Cancer Research, Department of Radiotherapy and Imaging, London, UK.

出版信息

Mol Ther. 2018 Aug 1;26(8):1875-1876. doi: 10.1016/j.ymthe.2018.07.002. Epub 2018 Jul 14.

DOI:10.1016/j.ymthe.2018.07.002
PMID:30017879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6094867/
Abstract
摘要

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本文引用的文献

1
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.预先存在的对溶瘤病毒的免疫增强了其免疫治疗效果。
Mol Ther. 2018 Apr 4;26(4):1008-1019. doi: 10.1016/j.ymthe.2018.01.019. Epub 2018 Jan 31.
2
Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade.静脉注射溶瘤单纯疱疹病毒(reovirus)至脑肿瘤患者,可使其对后续检查点阻断产生免疫原性。
Sci Transl Med. 2018 Jan 3;10(422). doi: 10.1126/scitranslmed.aam7577.
3
Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies.抗病毒免疫的抗肿瘤益处:溶瘤病毒治疗的一个被低估的方面。
Trends Immunol. 2018 Mar;39(3):209-221. doi: 10.1016/j.it.2017.11.006. Epub 2017 Dec 20.
4
Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus.细胞因子预处理可增强溶瘤病毒的全身递送和治疗效果。
Mol Ther. 2014 Oct;22(10):1851-63. doi: 10.1038/mt.2014.118. Epub 2014 Jun 24.
5
Leukemia cell-rhabdovirus vaccine: personalized immunotherapy for acute lymphoblastic leukemia.白血病细胞-横纹病毒疫苗:急性淋巴细胞白血病的个性化免疫疗法。
Clin Cancer Res. 2013 Jul 15;19(14):3832-43. doi: 10.1158/1078-0432.CCR-12-3199. Epub 2013 May 28.
6
Cell carriage, delivery, and selective replication of an oncolytic virus in tumor in patients.肿瘤患者中溶瘤病毒的细胞携带、传递和选择性复制。
Sci Transl Med. 2012 Jun 13;4(138):138ra77. doi: 10.1126/scitranslmed.3003578.
7
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans.静脉注射多机制癌症靶向溶瘤痘病毒在人体中的应用。
Nature. 2011 Aug 31;477(7362):99-102. doi: 10.1038/nature10358.
8
VEGF blockade decreases the tumor uptake of systemic oncolytic herpes virus but enhances therapeutic efficacy when given after virotherapy.血管内皮生长因子阻断会降低全身性溶瘤单纯疱疹病毒在肿瘤中的摄取,但在病毒治疗后给予时会增强治疗效果。
Gene Ther. 2010 Jul;17(7):922-9. doi: 10.1038/gt.2010.82. Epub 2010 May 27.
9
Immune-mediated antitumor activity of reovirus is required for therapy and is independent of direct viral oncolysis and replication.呼肠孤病毒的免疫介导抗肿瘤活性是治疗所必需的,且独立于直接的病毒溶瘤作用和复制。
Clin Cancer Res. 2009 Jul 1;15(13):4374-4381. doi: 10.1158/1078-0432.CCR-09-0334. Epub 2009 Jun 9.
10
Dendritic cells and T cells deliver oncolytic reovirus for tumour killing despite pre-existing anti-viral immunity.树突状细胞和 T 细胞递送溶瘤呼肠孤病毒以杀死肿瘤,尽管存在预先存在的抗病毒免疫。
Gene Ther. 2009 May;16(5):689-99. doi: 10.1038/gt.2009.29. Epub 2009 Mar 12.