Hennessy Morgan L, Bommareddy Praveen K, Boland Genevieve, Kaufman Howard L
Division of Surgical Oncology, Massachusetts General Hospital, 55 Fruit Street, Yawkey 7B, Boston, MA 02114, USA.
School of Graduate Studies, Graduate School of Biomedical Sciences, Rutgers University, 195 Little Albany Street, New Brunswick, NJ 08901, USA.
Surg Oncol Clin N Am. 2019 Jul;28(3):419-430. doi: 10.1016/j.soc.2019.02.007. Epub 2019 Apr 5.
Oncolytic viruses are naturally occurring, or genetically engineered viruses that can be administered via intralesional injections or intravenously to induce cell death in tumor cells and activate antitumor immune responses. This review summarizes several oncolytic viruses in preclinical and clinical trials, describes challenges in clinical implementation, and important areas of future investigation.
溶瘤病毒是天然存在的或经过基因工程改造的病毒，可通过瘤内注射或静脉注射给药，以诱导肿瘤细胞死亡并激活抗肿瘤免疫反应。本综述总结了几种处于临床前和临床试验阶段的溶瘤病毒，描述了临床应用中的挑战以及未来研究的重要领域。
