Unit of Dermatology and Venereology, Hospital Clínico Universitario San Cecilio, Av. De la Investigación s/n, Granada, Granada, Spain.
Departament of Psychiatry, Hospital Clínico Universitario San Cecilio, Granada, Spain.
Dermatol Ther. 2018 Jul;31(4):e12637. doi: 10.1111/dth.12637. Epub 2018 Jul 17.
Acneiform rash is a commonly reported side effect to certain types of medications, including antipsychotic agents. Its clinical presentation consists mainly of papulopustular lesions. Other types of lesions, such as nodular or cystic, can also be observed. Body distribution of the lesions follows a similar pattern to acne vulgaris. Depending on the severity of the case, drug-induced acne may be treated in different ways. In mild cases, the use of topical antibiotics and retinoids in combination is usually effective. With more severe forms, it may be necessary to add oral antibiotics, such as tetracyclines, but a good response is not always achieved. Identification of the drug responsible for the side-effect is mandatory in refractory eruptions. Herein, we present the case of an Aripiprazole-induced acneiform rash successfully treated with oral Isotretinoin. The treatment was effective and well tolerated and there was no need to discontinue the psychopharmacological medication. This is the first study to report this modality of treatment.
痤疮样皮疹是某些类型药物的常见不良反应，包括抗精神病药物。其临床表现主要为丘疹脓疱性损害。其他类型的损害，如结节或囊肿，也可能观察到。病变的身体分布与寻常痤疮相似。根据病情的严重程度，药物诱导的痤疮可能以不同的方式治疗。在轻度病例中，通常联合使用局部抗生素和维甲酸有效。对于更严重的形式，可能需要添加口服抗生素，如四环素，但并不总能取得良好的效果。对于难治性发作，必须确定引起不良反应的药物。在此，我们介绍了一例阿立哌唑诱导的痤疮样皮疹，用口服异维 A 酸成功治疗。治疗有效且耐受性良好，无需停用精神药理学药物。这是第一项报告这种治疗方式的研究。
