Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.
J Bone Joint Surg Am. 2018 Jul 18;100(14):1177-1183. doi: 10.2106/JBJS.17.01475.
Prescription of opioid analgesics is currently a common practice to relieve pain for musculoskeletal injuries in many regions of the world, especially in the United States and Canada. However, overprescription may underlie opioid misuse. Details on the utilization of prescribed opioids after nonoperative treatment of fractures and dislocations and whether consumption is related to injury location are unknown.
A total of 1,513 consecutive patients in China who underwent nonoperative treatment of a fracture and/or dislocation and who were prescribed opioids were studied over a 3-month period. Demographic information, alcohol consumption, smoking status, injury location, volume of prescription, and consumption patterns were recorded and were summarized.
The mean number of opioid pills prescribed was 14.7, and the mean patient-reported number of pills consumed was 7.2. Overall, 152 patients (10.0%) reported taking no prescribed opioid analgesics, and 924 patients (61.1%) ceased their prescribed opioids prior to completing the regimen. Injury location, alcohol consumption, and type of fracture or dislocation were all significantly associated with the patient-reported number of opioid pills consumed (p < 0.05). Patients with fracture and/or dislocation of the wrist or forearm (9.4 pills for 3.8 days); ankle, tibia, or fibula (9.3 pills for 3.7 days); or elbow or humerus (9.1 pills for 3.7 days) used more opioid pills compared with patients with injuries at other locations (not exceeding 6.4 pills and 3 days). When compared with patients who had no, low, or moderate daily alcohol consumption, there was more opioid use in patients with high daily alcohol consumption (8.5 pills for 3.4 days) and those with very high daily alcohol consumption (11.3 pills for 4.7 days). Patients with a dislocation and/or displaced fracture reported consuming 8.2 pills for 3.3 days, which was more than the consumption in patients with a nondisplaced fracture (6.2 pills for 2.5 days) and patients with an avulsion fracture (6.2 pills for 2.5 days).
Surgeons and patients should try to avoid opioids if possible after nonoperatively treated fractures and dislocations. If opioids are used, surgeons should prescribe the smallest dose for the shortest time after considering the injury location and type of fracture or dislocation.
Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
在世界上许多地区,包括美国和加拿大,开具阿片类镇痛药处方目前是缓解肌肉骨骼损伤疼痛的常见做法。然而,开具过量处方可能是阿片类药物滥用的原因。关于骨折和脱位的非手术治疗后开处的阿片类药物的使用情况,以及消耗是否与损伤部位有关的详细信息尚不清楚。
在中国,对 1513 名连续接受非手术治疗骨折和/或脱位且开具阿片类药物处方的患者进行了研究,研究时间为 3 个月。记录了患者的人口统计学信息、酒精摄入量、吸烟状况、损伤部位、处方量和消耗模式,并进行了总结。
开具的阿片类药丸平均数量为 14.7 片,患者报告的平均消耗药丸数量为 7.2 片。总体而言,有 152 名患者(10.0%)报告未服用任何开处的阿片类镇痛药,有 924 名患者(61.1%)在完成疗程之前停止服用开处的阿片类药物。损伤部位、酒精摄入量以及骨折或脱位类型均与患者报告的阿片类药物丸剂消耗量显著相关(p < 0.05)。手腕或前臂(3.8 天 9.4 片)、踝、胫骨或腓骨(3.7 天 9.3 片)或肘或肱骨(3.7 天 9.1 片)骨折或脱位的患者比其他部位损伤的患者使用更多的阿片类药物(不超过 6.4 片和 3 天)。与无、低或中度日酒精摄入量的患者相比,高日酒精摄入量(3.4 天 8.5 片)和极高日酒精摄入量(4.7 天 11.3 片)的患者使用更多的阿片类药物。有脱位和/或移位骨折的患者报告消耗 8.2 片,持续 3.3 天,比无移位骨折(2.5 天 6.2 片)和撕脱性骨折(2.5 天 6.2 片)患者的消耗更多。
对于非手术治疗的骨折和脱位患者,外科医生和患者应尽可能避免使用阿片类药物。如果使用阿片类药物,外科医生应在考虑损伤部位和骨折或脱位类型后,为最短时间开具最小剂量的药物。
预后 IV 级。有关证据水平的完整描述,请参见作者说明。