1 Rowan School of Osteopathic Medicine, Stratford, NJ, USA.
2 The Rothman Institute, Philadelphia, PA, USA.
Foot Ankle Int. 2018 Nov;39(11):1257-1265. doi: 10.1177/1071100718790243. Epub 2018 Aug 19.
Overprescription of narcotic pain medication is a major culprit in the present opioid epidemic plaguing the United States. The current literature on lower extremity opioid usage has limitations and would benefit from additional study. The purpose of our study was to prospectively assess opioid consumption patterns following outpatient orthopedic foot and ankle procedures.
Patients undergoing outpatient orthopedic foot and ankle procedures who met inclusion criteria had the following prospective information collected: patient demographics, preoperative health history, patient-reported outcomes, anesthesia type, procedure type, opioid prescription and consumption details. The morphine equivalent dose was calculated for each prescription and then converted to the equivalent of a 5-mg oxycodone "pill." Univariable analyses were performed to identify variables with a statistically robust association with opioid consumption for inclusion in a multivariable linear regression. A stepwise backward regression was then performed to identify independent predictors of opioid consumption. Postoperative opioid utilization was reported for 988 patients (mean age: 49 years).
Overall, patients consumed a median of 20 pills whereas the median number of pills prescribed was 40. This resulted in a utilization rate of 50% and 20 631 pills left unused. Independent factors associated with higher opioid consumption were anesthesia type ( P < .004), age <60 years ( P < .001), preoperative visual analog scale (VAS) pain report of >6 ( P = .008), and bony procedures ( P = .008); residual standard error 16.73 ( F=14.3, P < .001).
Our study found that patients who underwent orthopedic foot and ankle procedures were overprescribed narcotic medication by nearly twice the amount that was actually consumed. Although we identified 4 independent factors associated with opioid consumption, the large residual standard error suggests that there remains a substantial degree of unexplained variance of opioid consumption observed in the patient population. Physicians face a challenging task of setting appropriate protocols when balancing pain relief and generalizable guidelines.
Level II, prospective observational cohort study.
阿片类药物的过度处方是目前困扰美国的阿片类药物流行的主要罪魁祸首。目前关于下肢阿片类药物使用的文献存在局限性,需要进一步研究。我们的研究目的是前瞻性评估门诊骨科足踝手术后的阿片类药物使用模式。
符合纳入标准的接受门诊骨科足踝手术的患者,前瞻性收集以下信息:患者人口统计学、术前健康史、患者报告的结果、麻醉类型、手术类型、阿片类药物处方和使用细节。计算每张处方的吗啡当量剂量,然后转换为等效的 5 毫克羟考酮“药丸”。进行单变量分析,以确定与阿片类药物消耗具有统计学显著关联的变量,纳入多变量线性回归。然后进行逐步后退回归,以确定阿片类药物消耗的独立预测因子。988 例患者(平均年龄:49 岁)报告了术后阿片类药物的使用情况。
总体而言,患者消耗的中位数为 20 片,而处方的中位数为 40 片。这导致利用率为 50%,有 20631 片未使用。与较高阿片类药物消耗相关的独立因素包括麻醉类型( P <.004)、年龄<60 岁( P <.001)、术前视觉模拟量表(VAS)疼痛报告>6( P =.008)和骨手术( P =.008);残差标准误 16.73( F=14.3, P <.001)。
我们的研究发现,接受骨科足踝手术的患者被开具的阿片类药物处方量几乎是实际消耗量的两倍。尽管我们确定了与阿片类药物消耗相关的 4 个独立因素,但较大的残差标准误表明,在患者群体中,阿片类药物消耗仍然存在大量无法解释的差异。医生在平衡疼痛缓解和普遍适用的指南时,面临着制定适当方案的艰巨任务。
II 级,前瞻性观察队列研究。