Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, United Kingdom.
Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, United Kingdom.
J Clin Endocrinol Metab. 2018 Oct 1;103(10):3767-3772. doi: 10.1210/jc.2018-00786.
Obesity is a global epidemic, and there is a focus on identifying markers of obesity in children with a view to prevention.
We aimed to examine prospectively the association of maternal fasting lipids with adiposity in 5- to 7-year-old offspring in a large observational study.
Pregnant women (1612) were recruited to the Belfast center of the Hyperglycemia and Adverse Pregnancy Outcome study in a large tertiary maternity hospital at an average of 28 weeks' gestation. Maternal fasting total cholesterol, low-density lipoprotein-cholesterol, triglycerides, and high-density lipoprotein-cholesterol were estimated at 28 weeks' gestation. Offspring-mother pairs (819) were included in the current study, and adiposity was expressed as body mass index (BMI) z score (1990 British growth standard) and sum of skin-fold (SSF) thicknesses (triceps, subscapular, and suprailiac). Statistical significance was more rigorously defined as P < 0.01 to allow for multiple comparisons.
No linear relation was found between maternal lipids and offspring BMI z score or SSFs (P ≥ 0.01) using correlation analysis. With the use of logistic regression, there was no relation between maternal lipids and offspring adiposity controlled for birthweight z score, offspring age, offspring gender, smoking during pregnancy, offspring energy intake and physical activity, maternal BMI during pregnancy, and fasting glucose during pregnancy (P ≥ 0.01).
Maternal 28-week gestational fasting lipids are not associated with offspring BMI or subcutaneous adiposity at age 5 to 7 years.
肥胖是一种全球性的流行病，人们致力于寻找儿童肥胖的标志物，以期进行预防。
我们旨在通过一项大型观察性研究，前瞻性地检验孕妇空腹血脂与 5 至 7 岁子女肥胖的相关性。
在一家大型三级妇产医院，于妊娠 28 周左右平均招募了 1612 名孕妇参加 Belfast 中心的高血糖与不良妊娠结局研究，以评估孕妇的空腹总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高密度脂蛋白胆固醇。本研究共纳入 819 对母子，使用体重指数（BMI）z 评分（1990 年英国生长标准）和皮褶厚度总和（三头肌、肩胛下和髂嵴）来表示肥胖程度。统计学意义的定义更加严格，P < 0.01 以允许进行多次比较。
相关性分析显示，母体血脂与子女 BMI z 评分或 SSF 之间没有线性关系（P ≥ 0.01）。使用逻辑回归，在校正出生体重 z 评分、子女年龄、性别、孕期吸烟、子女能量摄入和体力活动、母亲孕期 BMI 和孕期空腹血糖后，母体血脂与子女肥胖之间没有关联（P ≥ 0.01）。
孕妇 28 周妊娠时的空腹血脂与子女 5 至 7 岁时的 BMI 或皮下脂肪肥胖无关。
