Rh 催化的空气和水分稳定的醛（酮）导向芳基 C(sp 3 )-H 键的氟磺酰基乙烯基化反应。
A Rh-Catalyzed Air and Moisture Tolerable Aldehyde (Ketone)-Directed Fluorosulfonylvinylation of Aryl C( sp)-H Bonds.
机构信息
State Key Laboratory of Silicate Materials for Architectures; and School of Chemistry, Chemical Engineering and Life Science , Wuhan University of Technology , 205 Luoshi Road , Wuhan , 430070 , China.
出版信息
Org Lett. 2018 Aug 3;20(15):4699-4703. doi: 10.1021/acs.orglett.8b02037. Epub 2018 Jul 18.
The first Rh-catalyzed activation of ortho sp C-H bonds of aldehydes (ketones) for monoselective coupling with ethenesulfonyl fluoride was accomplished without covalent or transient preinstallation of imines. The 42 examples revealed that the developed method has the advantage of a wide scope and functional-group tolerability. Application of this method for complicated natural product modification was also accomplished.
首次实现了首例 Rh 催化的醛（酮）的邻位 sp³ C-H 键与乙烯砜氟的单选择性偶联反应，无需共价键或瞬态亚胺的预安装。42 个实例表明，所开发的方法具有广泛的适用性和官能团耐受性的优点。该方法也成功应用于复杂天然产物的修饰。
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