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通过弱配位对钌（II/IV）催化的远程C-H氧化反应的见解。

Insights into Ruthenium(II/IV)-Catalyzed Distal C-H Oxygenation by Weak Coordination.

作者信息

Bu Qingqing, Kuniyil Rositha, Shen Zhigao, Gońka Elżbieta, Ackermann Lutz

机构信息

Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstraße 2, 37077, Göttingen, Germany.

出版信息

Chemistry. 2020 Dec 9;26(69):16450-16454. doi: 10.1002/chem.202003062. Epub 2020 Oct 29.

DOI:10.1002/chem.202003062
PMID:32596872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7756554/
Abstract

C-H hydroxylation of aryl acetamides and alkyl phenylacetyl esters was accomplished via challenging distal weak O-coordination by versatile ruthenium(II/IV) catalysis. The ruthenium(II)-catalyzed C-H oxygenation of aryl acetamides proceeded through C-H activation, ruthenium(II/IV) oxidation and reductive elimination, thus providing step-economical access to valuable phenols. The p-cymene-ruthenium(II/IV) manifold was established by detailed experimental and DFT-computational studies.

摘要

通过通用的钌（II/IV）催化实现具有挑战性的远端弱氧配位，完成了芳基乙酰胺和烷基苯乙酰酯的C-H羟基化反应。钌（II）催化的芳基乙酰胺的C-H氧化反应通过C-H活化、钌（II/IV）氧化和还原消除进行，从而为获得有价值的酚类提供了步骤经济的途径。通过详细的实验和DFT计算研究建立了对异丙基苯-钌（II/IV）反应历程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/91b4a053f87d/CHEM-26-16450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/4690f4be4668/CHEM-26-16450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/dc15b44d26ae/CHEM-26-16450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/63b50b3e8ed5/CHEM-26-16450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/7e6fb4826839/CHEM-26-16450-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/8ab94b8bcc8a/CHEM-26-16450-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/91b4a053f87d/CHEM-26-16450-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/4690f4be4668/CHEM-26-16450-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/dc15b44d26ae/CHEM-26-16450-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/63b50b3e8ed5/CHEM-26-16450-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/7e6fb4826839/CHEM-26-16450-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/8ab94b8bcc8a/CHEM-26-16450-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1018/7756554/91b4a053f87d/CHEM-26-16450-g002.jpg

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Angew Chem Int Ed Engl. 2020 Feb 17;59(8):3184-3189. doi: 10.1002/anie.201914226. Epub 2020 Jan 9.
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7
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