肿瘤细胞内在的阴阳决定免疫逃逸。
A Tumor Cell-Intrinsic Yin-Yang Determining Immune Evasion.
机构信息
Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Massachusetts Institute of Technology, Department of Biology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard S. and Linda B. Stern Career Development Professor, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
出版信息
Immunity. 2018 Jul 17;49(1):11-13. doi: 10.1016/j.immuni.2018.07.001.
Abstract
Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and reduces responsiveness to immunotherapy.
摘要
胰腺导管腺癌（PDAC）大多对免疫疗法有抗性。在本期《免疫》杂志中，Li 等人（2018 年）构建了一个克隆 PDAC 肿瘤文库，以研究塑造抗肿瘤免疫反应的肿瘤内在特征，并发现肿瘤细胞衍生的 CXCL1 直接抑制 T 细胞浸润并降低对免疫治疗的反应性。
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