Dolgova Olga, Lao Oscar
Population Genomics Group, Centre Nacional d'Anàlisi Genòmica, Centre de Regulació Genòmica (CRG-CNAG), Parc Científic de Barcelona, Baldiri Reixac 4, 08028 Barcelona, Catalonia, Spain.
Genes (Basel). 2018 Jul 18;9(7):358. doi: 10.3390/genes9070358.
The demographic history of anatomically modern humans (AMH) involves multiple migration events, population extinctions and genetic adaptations. As genome-wide data from complete genome sequencing becomes increasingly abundant and available even from extinct hominins, new insights of the evolutionary history of our species are discovered. It is currently known that AMH interbred with archaic hominins once they left the African continent. Current non-African human genomes carry fragments of archaic origin. This review focuses on the fitness consequences of archaic interbreeding in current human populations. We discuss new insights and challenges that researchers face when interpreting the potential impact of introgression on fitness and testing hypotheses about the role of selection within the context of health and disease.
解剖学意义上的现代人类（AMH）的人口历史涉及多次迁徙事件、种群灭绝和基因适应。随着全基因组测序的全基因组数据变得越来越丰富，甚至可以从已灭绝的古人类中获得，我们对人类物种进化历史有了新的认识。目前已知，AMH一旦离开非洲大陆，就与古代人类杂交。目前的非非洲人类基因组携带古老起源的片段。这篇综述重点关注当前人类群体中古代杂交对适应性的影响。我们讨论了研究人员在解释基因渗入对适应性的潜在影响以及在健康和疾病背景下检验选择作用的假设时所面临的新见解和挑战。
