表现为儿童青光眼的虹膜黑色素瘤。
Iris melanoma presenting as childhood glaucoma.
作者信息
Gapsis Briana C, Warren Nichelle A, Nutaitis Matthew J, Bonaparte Leah A, Cooper Samuel L, Ashenafi Michael, Grossniklaus Hans E, Magrath George N
机构信息
Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.
Department of Radiation Oncology, Medical University of South Carolina, Charleston, SC, USA.
出版信息
Am J Ophthalmol Case Rep. 2018 May 26;11:56-60. doi: 10.1016/j.ajoc.2018.05.009. eCollection 2018 Sep.
PURPOSE
To describe the natural history and management of a rare case of iris melanoma in a pediatric patient.
OBSERVATIONS
A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Trans-corneal fine needle aspirate biopsy demonstrated malignant melanoma of the iris. The patient subsequently underwent Iodine-125 plaque brachytherapy for the tumor.
CONCLUSIONS
and Importance: Early identification and treatment of iris melanoma may be associated with decreased risk of local progression and metastatic disease. Treatment of glaucoma in conjunction with uveal melanoma is complicated by tumor specific considerations, including treatment of the tumor and prevention of metastasis.
目的
描述一名儿科患者罕见的虹膜黑色素瘤的自然病史及治疗情况。
观察结果
一名白种女性7岁时出现左瞳孔异常，9岁时虹膜出现进行性变化，11岁时眼压显著升高且视神经凹陷进展。发现其虹膜上有色素沉着病变并侵犯房角。经角膜细针穿刺活检显示为虹膜恶性黑色素瘤。该患者随后接受了碘-125敷贴近距离放射治疗。
结论及重要性
虹膜黑色素瘤的早期识别和治疗可能与局部进展和转移性疾病风险降低有关。葡萄膜黑色素瘤合并青光眼的治疗因肿瘤特异性因素而变得复杂，包括肿瘤治疗和转移预防。
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