• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

佛波酯对正常和ras转化的NIH3T3细胞β-肾上腺素能反应的不同影响。

Differential effects of phorbol ester on the beta-adrenergic response of normal and ras-transformed NIH3T3 cells.

作者信息

Garte S J

出版信息

Biochem Biophys Res Commun. 1985 Dec 17;133(2):702-8. doi: 10.1016/0006-291x(85)90961-1.

DOI:10.1016/0006-291x(85)90961-1
PMID:3002353
Abstract

The basal and isoproterenol stimulated levels of cyclic AMP in NIH3T3 and H-ras transformed NIH3T3 cells were equivalent. In exponentially growing cells, the phorbol ester 12-O-tetradecanoyl-13-acetate (TPA) inhibited the beta-adrenergic response of NIH3T3 cells, but not of the ras-transformed line. Another line of NIH3T3 cells transformed by a non-ras gene exhibited the normal loss of beta-adrenergic response by the tumor promoter. These results are consistent with a role for p21 in signal transduction related to the effects of TPA.

摘要

NIH3T3细胞及H-ras转化的NIH3T3细胞中环磷酸腺苷（cAMP）的基础水平及异丙肾上腺素刺激后的水平相当。在指数生长期的细胞中，佛波酯12-O-十四酰基-13-乙酸酯（TPA）抑制NIH3T3细胞的β-肾上腺素能反应，但不抑制ras转化细胞系的该反应。另一株由非ras基因转化的NIH3T3细胞系表现出肿瘤启动子使其β-肾上腺素能反应正常丧失。这些结果与p21在与TPA作用相关的信号转导中的作用一致。

相似文献

1
Differential effects of phorbol ester on the beta-adrenergic response of normal and ras-transformed NIH3T3 cells.佛波酯对正常和ras转化的NIH3T3细胞β-肾上腺素能反应的不同影响。
Biochem Biophys Res Commun. 1985 Dec 17;133(2):702-8. doi: 10.1016/0006-291x(85)90961-1.
2
The effect of the phorbol ester tumor promoters on the basal and catecholamine-stimulated levels of cyclic adenosine 3':5'-monophosphate in mouse skin and epidermis in vivo.佛波酯肿瘤启动子对小鼠皮肤和表皮中体内环磷酸腺苷（cAMP）基础水平及儿茶酚胺刺激水平的影响。
Cancer Res. 1977 Mar;37(3):665-9.
3
Tumour promoter uncouples beta-adrenergic receptor from adenyl cyclase in mouse epidermis.肿瘤促进剂使小鼠表皮中的β-肾上腺素能受体与腺苷酸环化酶解偶联。
Nature. 1980 Mar 13;284(5752):171-3. doi: 10.1038/284171a0.
4
Antagonism between phorbol myristate acetate and butyric acid on isoproterenol elevation of cyclic adenosine 3':5'-monophosphate and their effects on beta-adrenergic receptors in mouse epidermis.佛波醇肉豆蔻酸酯乙酸盐与丁酸对异丙肾上腺素升高环磷酸腺苷的拮抗作用及其对小鼠表皮β-肾上腺素能受体的影响。
Cancer Res. 1980 Feb;40(2):240-4.
5
Effect of 12-O-tetradecanoyl-phorbol-13-acetate on beta-adrenergic receptors of newborn mouse skin.12-O-十四烷酰佛波醇-13-乙酸酯对新生小鼠皮肤β-肾上腺素能受体的影响。
Indian J Biochem Biophys. 1982 Dec;19(6):408-10.
6
Inhibition of beta-adrenergic response in cultured epidermal cells by phorbol myristate acetate.
Carcinogenesis. 1983;4(7):939-40. doi: 10.1093/carcin/4.7.939.
7
Comparison of the effects of age and phorbol myristate acetate on the beta-adrenergic system in mouse epidermis.
Mech Ageing Dev. 1982 Mar;18(3):209-14. doi: 10.1016/0047-6374(82)90110-5.
8
Dissociation of increases in levels of 3':5'-cyclic AMP and 3':5'-cyclic GMP from induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate in mouse epidermis in vivo.在体内小鼠表皮中，肿瘤启动子12-O-十四烷酰佛波醇-13-乙酸酯诱导鸟氨酸脱羧酶时，3':5'-环磷酸腺苷（cAMP）和3':5'-环磷酸鸟苷（cGMP）水平升高的解离情况。
Proc Natl Acad Sci U S A. 1977 Feb;74(2):657-61. doi: 10.1073/pnas.74.2.657.
9
Enhancement of hormone action by a phorbol ester and anti-tubulin alkaloids involves different mechanisms.佛波酯和抗微管蛋白生物碱对激素作用的增强涉及不同机制。
Biochim Biophys Acta. 1982 Apr 29;720(2):120-5. doi: 10.1016/0167-4889(82)90002-7.
10
Human Harvey-ras is biochemically different from Kirsten- or N-ras.人类哈维 - 鼠肉瘤病毒癌基因同源物（Human Harvey-ras）在生物化学性质上与 Kirsten - 鼠肉瘤病毒癌基因同源物（Kirsten-ras）或神经母细胞瘤 ras 基因（N-ras）不同。
Oncogene. 1991 May;6(5):731-7.

引用本文的文献

1
Establishment of a rat nasal epithelial tumor cell line.大鼠鼻上皮肿瘤细胞系的建立。
In Vitro Cell Dev Biol. 1987 Apr;23(4):274-8. doi: 10.1007/BF02623710.