Gautam Chandkiram, Chakravarty Dibyendu, Gautam Amarendra, Tiwary Chandra Sekhar, Woellner Cristiano Francisco, Mishra Vijay Kumar, Ahmad Naseer, Ozden Sehmus, Jose Sujin, Biradar Santoshkumar, Vajtai Robert, Trivedi Ritu, Galvao Douglas S, Ajayan Pulickel M
Department of Materials Science and Nano Engineering, Rice University, Houston, Texas 77005, United States.
Department of Physics, University of Lucknow, Lucknow, Uttar Pradesh 226007, India.
ACS Omega. 2018 Jun 30;3(6):6013-6021. doi: 10.1021/acsomega.8b00707. Epub 2018 Jun 4.
Recent advances and demands in biomedical applications drive a large amount of research to synthesize easily scalable low-density, high-strength, and wear-resistant biomaterials. The chemical inertness with low density combined with high strength makes h-BN one of the promising materials for such application. In this work, three-dimensional hexagonal boron nitride (h-BN) interconnected with boron trioxide (BO) was prepared by easily scalable and energy efficient spark plasma sintering (SPS) process. The composite structure shows significant densification (1.6-1.9 g/cm) and high surface area (0.97-14.5 m/g) at an extremely low SPS temperature of 250 °C. A high compressive strength of 291 MPa with a reasonably good wear resistance was obtained for the composite structure. The formation of strong covalent bonds between h-BN and BO was formulated and established by molecular dynamics simulation. The composite showed significant effect on cell viability/proliferation. It shows a high mineralized nodule formation over the control, which suggests its use as a possible osteogenic agent in bone formation.
生物医学应用领域的最新进展和需求推动了大量研究，旨在合成易于扩展的低密度、高强度和耐磨生物材料。低密度与高强度相结合的化学惰性使六方氮化硼成为此类应用中颇具前景的材料之一。在这项工作中，通过易于扩展且节能的放电等离子烧结（SPS）工艺制备了与三氧化二硼（BO）互连的三维六方氮化硼（h-BN）。该复合结构在极低的250°C SPS温度下显示出显著的致密化（1.6 - 1.9 g/cm）和高表面积（0.97 - 14.5 m²/g）。该复合结构获得了291 MPa的高抗压强度以及相当良好的耐磨性。通过分子动力学模拟确定并证实了h-BN与BO之间形成了强共价键。该复合材料对细胞活力/增殖具有显著影响。与对照组相比，它显示出高矿化结节形成，这表明其可作为骨形成中一种可能的成骨剂。
