Gautam Amarendra, Gautam Chandkiram, Mishra Monalisa, Mishra Vijay Kumar, Hussain Ajaz, Sahu Swetapadma, Nanda Reetuparna, Kisan Bikash, Biradar Santoshkumar, Gautam Rakesh Kumar
Advanced Glass and Glass Ceramics Research Laboratory, Department of Physics, University of Lucknow Lucknow-226007 India
Neural Developmental Biology Lab, Department of Life Science, National Institute of Technology Rourkela Odisha-769008 India.
RSC Adv. 2019 Dec 11;9(70):40977-40996. doi: 10.1039/c9ra07835e. eCollection 2019 Dec 9.
In this study, six compositions in the system [(h-BN)-(100 - )ZrO] (10 ≤ ≤ 90) were synthesized by a bottom up approach, , the solid-state reaction technique. XRD results showed the formation of a novel and main phase of zirconium oxynitrate ZrO(NO) and SEM exhibited mixed morphology of layered and stacked h-BN nanosheets with ZrO grains. The composite sample 10 wt% h-BN + 90 wt% ZrO (10B90Z) showed outstanding mechanical properties for different parameters, , density (3.12 g cm), Young's modulus (10.10 GPa), toughness (2.56 MJ m), and maximum mechanical strength (227.33 MPa). The current study further checked the toxicity of composite 10B90Z and composite 90B10Z using . The composite 10B90Z showed less cytotoxicity in this model, while the composite 90B10Z showed higher toxicity in terms of organ development as well as internal damage of the gut mostly at the lower concentrations of 1, 10, and 25 μg mL. Altogether, the current study proposes the composite 10B90Z as an ideal compound for applications in biomedical research. This composite 10B90Z displays remarkable mechanical and biological performances, due to which we recommend this composition for various biomedical applications.
在本研究中,通过自下而上的方法,即固态反应技术,合成了体系[(h-BN)-(100 - )ZrO](10 ≤ ≤ 90)中的六种成分。X射线衍射(XRD)结果表明形成了一种新型的主要相——硝酸氧锆ZrO(NO),扫描电子显微镜(SEM)显示了层状和堆叠的h-BN纳米片与ZrO晶粒的混合形态。复合样品10 wt% h-BN + 90 wt% ZrO(10B90Z)在不同参数方面表现出优异的力学性能,即密度(3.12 g/cm³)、杨氏模量(10.10 GPa)、韧性(2.56 MJ/m³)和最大机械强度(227.33 MPa)。当前研究进一步使用 检查了复合样品10B90Z和复合样品90B10Z的 毒性。在该模型中,复合样品10B90Z显示出较低的细胞毒性,而复合样品90B10Z在器官发育以及肠道内部损伤方面表现出较高的毒性,主要是在1、10和25 μg/mL的较低浓度下。总之,当前研究提出复合样品10B90Z是生物医学研究应用中的理想化合物。这种复合样品10B90Z表现出卓越的机械和生物学性能,因此我们推荐该成分用于各种生物医学应用。