哇巴因不敏感、卤化物敏感的犬髂动脉对铊离子的摄取

Ouabain-insensitive, halide-sensitive Tl+ uptake by canine iliac arteries.

作者信息

Rangachari P K, McWade D

出版信息

Biochim Biophys Acta. 1986 Jan 29;854(2):251-6. doi: 10.1016/0005-2736(86)90117-3.

Abstract

Ouabain-insensitive Tl+ uptake by canine iliac arteries was studied. A significant fraction was halide-sensitive, with Br- substituting well for Cl-. The halide-sensitive component was inhibited by diuretics (MK196, bumetanide), PCMBS, low temperatures and external cations K+, Rb+. External but not internal Na+ was necessary for the uptake process. The process was not sensitive to disulphonic stilbenes. The halide-sensitive uptake appears to represent the operation of a (Na+/K+/Cl-)-cotransport process in arteries.

摘要

研究了犬髂动脉对哇巴因不敏感的铊离子摄取。很大一部分对卤化物敏感，溴离子可很好地替代氯离子。卤化物敏感成分受到利尿剂（MK196、布美他尼）、对氯汞苯甲酸、低温以及外部阳离子钾离子、铷离子的抑制。摄取过程需要外部而非内部的钠离子。该过程对二磺基芪不敏感。卤化物敏感摄取似乎代表了动脉中一种（钠离子/钾离子/氯离子）协同转运过程的运作。