Pekny Milos, Wilhelmsson Ulrika, Tatlisumak Turgut, Pekna Marcela
Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Box 440, 40530 Gothenburg, Sweden; Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; University of Newcastle, Newcastle, NSW, Australia.
Center for Brain Repair, Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Box 440, 40530 Gothenburg, Sweden.
Neurosci Lett. 2019 Jan 10;689:45-55. doi: 10.1016/j.neulet.2018.07.021. Epub 2018 Jul 17.
Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.
中风是对中枢神经系统（CNS）的急性损伤，它会在急性、亚急性以及后期引发一系列反应，星形胶质细胞会显著参与其中。中风急性期的星形胶质细胞激活和反应性胶质增生可限制组织损伤并有助于内环境稳态的恢复。星形胶质细胞还控制着神经可塑性的许多方面，而神经可塑性是功能恢复的基础。在此，我们讨论中间丝（纳米丝）和补体系统的概念，它们是星形胶质细胞对损伤反应的两个切入点，都为调节星形胶质细胞功能和反应性胶质增生的新型治疗策略提供了有吸引力的机会。
