Department of Biology/Chemistry, Biochemistry Section, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany.
Department of Biology/Chemistry, Molecular Membrane Biology Group, University of Osnabrück, Barbarastrasse 13, 49076 Osnabrück, Germany; Center of Cellular Nanoanalytics of the University of Osnabrück (CellNanOs), Barbarastrasse 11, 49076 Osnabrück, Germany.
Trends Cell Biol. 2018 Nov;28(11):957-970. doi: 10.1016/j.tcb.2018.06.007. Epub 2018 Jul 17.
Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.
真核细胞维持着高度组织化的内体溶酶体系统。该系统调节质膜的蛋白质和脂质含量，参与细胞内质量控制机制，并需要有效地去除受损的细胞器。这个复杂的网络包括一个将膜蛋白和可能的脂质再循环进入溶酶体的内体膜系统。此外，溶酶体降解为细胞提供了用于进一步生长的大分子物质。在这篇综述中，我们主要关注小 Rab GTPases Rab5 和 Rab7 作为细胞器标记物的作用，以及它们作为内体和溶酶体上多种效应物的相互作用因子的作用，并强调它们在膜动力学，特别是沿内体溶酶体途径融合中的作用。
