外源性小鼠干扰素对2型小鼠肝炎病毒诱导的小鼠暴发性肝炎的影响。
Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2.
作者信息
Kato Y, Noda Y, Unoura M, Tanaka N, Kobayashi K, Hattori N, Hatano K, Kobayashi S
出版信息
Dig Dis Sci. 1986 Feb;31(2):177-80. doi: 10.1007/BF01300705.
Abstract
We investigated the effect of exogenous mouse alpha- + beta-interferon produced by mouse L cells on the growth of mouse hepatitis virus type 2 (MHV-2) in the liver, the development of liver cell necrosis, and survival in murine fulminant hepatitis induced by MHV-2. Murine fulminant hepatitis was induced in 4-week-old male ICR mice by intraperitoneal inoculation of MHV-2. Mouse interferon (10(3) IU/mouse/day) was intraperitoneally injected every day. Exogenous mouse interferon suppressed both the growth of MHV-2 in the liver tissue and development of liver cell necrosis, and prolonged the survival. It was also found that the earlier mouse interferon was administered, the greater was the prolongation of survival.
摘要
我们研究了小鼠L细胞产生的外源性小鼠α +β干扰素对2型小鼠肝炎病毒（MHV - 2）在肝脏中的生长、肝细胞坏死的发展以及由MHV - 2诱导的小鼠暴发性肝炎中存活率的影响。通过腹腔接种MHV - 2在4周龄雄性ICR小鼠中诱导小鼠暴发性肝炎。每天腹腔注射小鼠干扰素（10³IU/小鼠/天）。外源性小鼠干扰素既抑制了MHV - 2在肝组织中的生长，也抑制了肝细胞坏死的发展，并延长了存活时间。还发现小鼠干扰素给药越早，存活时间延长得越多。
相似文献
1
Effect of exogenous mouse interferon on murine fulminant hepatitis induced by mouse hepatitis virus type 2.外源性小鼠干扰素对2型小鼠肝炎病毒诱导的小鼠暴发性肝炎的影响。
Dig Dis Sci. 1986 Feb;31(2):177-80. doi: 10.1007/BF01300705.
2
Synergistic antiviral effect of a combination of mouse interferon-alpha and interferon-gamma on mouse hepatitis virus.小鼠α干扰素与γ干扰素联合应用对小鼠肝炎病毒的协同抗病毒作用
J Med Virol. 2003 Feb;69(2):188-94. doi: 10.1002/jmv.10286.
3
Protective effect of OK-432 (streptococcal preparation) on murine fulminant hepatitis following mouse hepatitis virus infection.溶链菌制剂OK-432对小鼠肝炎病毒感染后小鼠暴发性肝炎的保护作用。
J Gastroenterol Hepatol. 1990 Jul-Aug;5(4):395-401. doi: 10.1111/j.1440-1746.1990.tb01416.x.
4
Protective effect of recombinant murine interferon beta against mouse hepatitis virus infection.
Antiviral Res. 1987 Sep;8(2):85-95. doi: 10.1016/0166-3542(87)90079-9.
5
A disparate subset of double-negative T cells contributes to the outcome of murine fulminant viral hepatitis via effector molecule fibrinogen-like protein 2.双阴性T细胞的一个不同亚群通过效应分子纤维蛋白原样蛋白2影响小鼠暴发性病毒性肝炎的转归。
Immunol Res. 2016 Apr;64(2):518-30. doi: 10.1007/s12026-015-8727-0.
6
Clara Cell 10 kDa Protein Alleviates Murine Hepatitis Virus Strain 3-Induced Fulminant Hepatitis by Inhibiting Fibrinogen-Like Protein 2 Expression.克拉拉细胞 10kDa 蛋白通过抑制纤维蛋白原样蛋白 2 的表达缓解 3 型鼠肝炎病毒诱导的暴发性肝炎。
Front Immunol. 2018 Dec 13;9:2935. doi: 10.3389/fimmu.2018.02935. eCollection 2018.
7
Hepatitogenicity of three plaque purified mutants of hepatotropic mouse hepatitis virus, MHV-2.嗜肝性小鼠肝炎病毒MHV-2的三个蚀斑纯化突变体的肝致病性
J Vet Med Sci. 1991 Aug;53(4):655-61. doi: 10.1292/jvms.53.655.
8
[The functions of liver natural killer cells in murine fulminant hepatitis induced by murine hepatitis virus strain 3].[肝脏自然杀伤细胞在鼠肝炎病毒3型诱导的小鼠暴发性肝炎中的作用]
Zhonghua Gan Zang Bing Za Zhi. 2008 Sep;16(9):660-4.
9
Toll-like receptor-2 exacerbates murine acute viral hepatitis.Toll样受体2加剧小鼠急性病毒性肝炎。
Immunology. 2016 Oct;149(2):204-24. doi: 10.1111/imm.12627. Epub 2016 Aug 10.
10
Macrophage scavenger receptor 1 contributes to pathogenesis of fulminant hepatitis via neutrophil-mediated complement activation.巨噬细胞清道夫受体 1 通过中性粒细胞介导的补体激活促进暴发性肝炎的发病机制。
J Hepatol. 2018 Apr;68(4):733-743. doi: 10.1016/j.jhep.2017.11.010. Epub 2017 Nov 14.
引用本文的文献
1
Murine coronavirus delays expression of a subset of interferon-stimulated genes.鼠冠状病毒延迟了一组干扰素刺激基因的表达。
J Virol. 2010 Jun;84(11):5656-69. doi: 10.1128/JVI.00211-10. Epub 2010 Mar 31.
2
Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response.鼠冠状病毒与I型干扰素反应的细胞类型依赖性相互作用。
Viruses. 2009 Dec 1;1(3):689-712. doi: 10.3390/v1030689.
3
Synergistic antiviral effect of a combination of mouse interferon-alpha and interferon-gamma on mouse hepatitis virus.小鼠α干扰素与γ干扰素联合应用对小鼠肝炎病毒的协同抗病毒作用
J Med Virol. 2003 Feb;69(2):188-94. doi: 10.1002/jmv.10286.
4
Regulated and prolonged expression of mIFN(alpha) in immunocompetent mice mediated by a helper-dependent adenovirus vector.由辅助依赖型腺病毒载体介导的免疫活性小鼠中mIFN（α）的调控和延长表达。
Gene Ther. 2001 Dec;8(24):1817-25. doi: 10.1038/sj.gt.3301596.
5
Liver-specific alpha 2 interferon gene expression results in protection from induced hepatitis.肝脏特异性α2干扰素基因表达可导致对诱导性肝炎的保护作用。
J Virol. 2000 May;74(10):4816-23. doi: 10.1128/jvi.74.10.4816-4823.2000.
6
Fulminant hepatitis.暴发性肝炎
Springer Semin Immunopathol. 1990;12(1):33-45. doi: 10.1007/BF00192680.
本文引用的文献
1
MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITY.小鼠巨噬细胞作为小鼠肝炎病毒的宿主细胞及其易感性的遗传基础
Proc Natl Acad Sci U S A. 1960 Aug;46(8):1065-75. doi: 10.1073/pnas.46.8.1065.
2
A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES.一种用于比较任意单删失样本的广义威尔科克森检验。
Biometrika. 1965 Jun;52:203-23.
3
Interferon production with multitray culture system on a large scale.使用多盘培养系统大规模生产干扰素。
J Interferon Res. 1984;4(1):9-16. doi: 10.1089/jir.1984.4.9.
4
The effect of mouse hepatitis virus infection on the microcirculation of the liver.小鼠肝炎病毒感染对肝脏微循环的影响。
Hepatology. 1983 Nov-Dec;3(6):964-73. doi: 10.1002/hep.1840030614.
5
6
Comparison of mouse hepatitis virus strains for pathogenicity in weanling mice infected by various routes.通过不同途径感染断奶小鼠的情况下，小鼠肝炎病毒毒株致病性的比较。
Arch Virol. 1981;70(1):69-73. doi: 10.1007/BF01320795.
7
Activation of natural killer cells and induction of interferon after injection of mouse hepatitis virus type 3 in mice.给小鼠注射3型小鼠肝炎病毒后自然杀伤细胞的激活及干扰素的诱导
Infect Immun. 1982 Mar;35(3):869-73. doi: 10.1128/iai.35.3.869-873.1982.
8
Interferon system in acute viral hepatitis.急性病毒性肝炎中的干扰素系统。
Lancet. 1982 Mar 13;1(8272):592-4. doi: 10.1016/s0140-6736(82)91751-2.
9
Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture.小鼠肝炎病毒（MHV-2）在小鼠细胞系DBT培养物中的复制及蚀斑形成
Arch Gesamte Virusforsch. 1974;44(3):298-302. doi: 10.1007/BF01240618.
10
Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus.对小鼠肝炎病毒体外和体内易感性的阻断
J Exp Med. 1977 Nov 1;146(5):1467-72. doi: 10.1084/jem.146.5.1467.
Zotero 插件