对小鼠肝炎病毒体外和体内易感性的阻断
Blocking of in vitro and in vivo susceptibility to mouse hepatitis virus.
作者信息
Weiser W Y, Bang F B
出版信息
J Exp Med. 1977 Nov 1;146(5):1467-72. doi: 10.1084/jem.146.5.1467.
Abstract
By pretreatment with concanavalin A (Con A) both in vivo and in vitro genetically susceptible mice and their cultured macrophages have been converted to animals and cells which are phenotypically resistant to mouse hepatitus virus (MHV). Con A at 1.0 mg/mouse decreased the mortality from 100% to less than 40% by inducing a prominent inflammatory response, increasing the number of macrophages in the virus inoculation site, and producing a population of macrophages not uniformly susceptible to the virus. In addition, mediators derived from Con A-treated spleen cells conferred resistance to normally susceptible syngeneic macrophages to 100 TCID50 of MHV.
摘要
通过在体内和体外使用伴刀豆球蛋白A（Con A）进行预处理，基因易感小鼠及其培养的巨噬细胞已转变为对小鼠肝炎病毒（MHV）具有表型抗性的动物和细胞。每只小鼠注射1.0毫克Con A，通过引发显著的炎症反应、增加病毒接种部位的巨噬细胞数量以及产生一群对病毒并非均一敏感的巨噬细胞，可将死亡率从100%降至40%以下。此外，Con A处理的脾细胞衍生的介质赋予了正常易感的同基因巨噬细胞对100个半数组织培养感染剂量（TCID50）的MHV的抗性。
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