Department of Gastroenterology, Changhai Hospital , Second Military Medical University , 200433 Shanghai , P. R. China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics , Chinese Academy of Sciences , 200050 Shanghai , P. R. China.
ACS Appl Mater Interfaces. 2018 Aug 8;10(31):26108-26117. doi: 10.1021/acsami.8b10345. Epub 2018 Jul 30.
The overproduction of reactive oxygen species (ROS) is central to the progression of inflammatory bowel disease (IBD), which may be the potential therapeutic target. Prussian blue (PB) nanoparticles with good biosafety can act as an artificial nanozyme, effectively scavenging ROS. To date, PB-based nanomaterials have not been developed and utilized for treatment of IBD. In this study, poly(vinylpyrrolidone)-modified Prussian blue (PPB) nanoparticles are constructed with good physiological stability and biosafety by a simple and efficient method. The prepared PPBs with capabilities of scavenging ROS and inhibiting proinflammatory cytokine significantly reduce colitis in mice without distinct side effects via intravenous administration. This report provides a demonstration of the protective effect of PB-based nanomedicine against IBD in living animals, offering hope and a potential alternative treatment option for patients suffering from IBD.
活性氧（ROS）的过度产生是炎症性肠病（IBD）进展的核心，这可能是潜在的治疗靶点。普鲁士蓝（PB）纳米颗粒具有良好的生物安全性，可以作为一种人工纳米酶，有效清除 ROS。迄今为止，尚未开发和利用基于 PB 的纳米材料来治疗 IBD。在这项研究中，通过一种简单有效的方法构建了具有良好生理稳定性和生物安全性的聚乙烯吡咯烷酮修饰的普鲁士蓝（PPB）纳米颗粒。所制备的 PPB 具有清除 ROS 和抑制促炎细胞因子的能力，通过静脉注射可显著减轻小鼠的结肠炎，且没有明显的副作用。本报告在活体动物中展示了基于 PB 的纳米药物对 IBD 的保护作用，为患有 IBD 的患者带来了希望和潜在的替代治疗选择。
