Lei Fang, Huang Qizhen, Zhang Chengfeng, Lin Youhui, Zhang Yan, Wang Faming
School of Public Health, Nantong University, Nantong, 226019, China.
Institute of Special Environmental Medicine, Nantong University, Nantong, 226019, China.
Mater Today Bio. 2025 Jun 21;33:102008. doi: 10.1016/j.mtbio.2025.102008. eCollection 2025 Aug.
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gut that has caused an escalating burden on the global healthcare system in recent years. Researchers have been actively seeking innovative therapeutic strategies to combat this intractable disease. Recent advances in nanozyme technology have opened up new avenues for the development of novel therapeutic strategies for IBD. This review provides a comprehensive overview of the related works in the developments and applications of different nanozymes for IBD therapy. By overviewing the known pathogenesis of IBD and pathogenesis-guided applications of nanozymes in IBD therapy, this review highlights the opportunities for nanozyme-based strategies to address IBD via the underlying mechanisms. This review also examines the current state of nanozyme research in IBD, including the design and application of nanozymes, and discusses the challenges and future directions for this emerging field. In addition, by integrating the understanding of IBD pathogenesis with the development of nanozyme technology, this review aims to stimulate further research to uncover new opportunities for this debilitating disease.
炎症性肠病（IBD）是一种肠道慢性炎症性疾病，近年来给全球医疗保健系统带来了日益加重的负担。研究人员一直在积极寻求创新的治疗策略来对抗这种难治性疾病。纳米酶技术的最新进展为开发IBD新型治疗策略开辟了新途径。本综述全面概述了不同纳米酶在IBD治疗中的开发和应用相关工作。通过概述IBD已知的发病机制以及纳米酶在IBD治疗中基于发病机制的应用，本综述突出了基于纳米酶的策略通过潜在机制解决IBD的机会。本综述还研究了IBD中纳米酶研究的现状，包括纳米酶的设计和应用，并讨论了这一新兴领域的挑战和未来方向。此外，通过将对IBD发病机制的理解与纳米酶技术的发展相结合，本综述旨在激发进一步的研究，以发现针对这种使人衰弱疾病的新机会。
