Zheng Wei, Chen Kai, Peng Chuan, Yin Shao-Han, Pan Yong-Ying, Liu Min, Lin Shi-Yang, Pei Xiao-Qing
1 Department of Ultrasound, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine , Guangzhou , China.
2 Department of Radiotherapy, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine , Guangzhou , China.
Br J Radiol. 2018 Nov;91(1091):20170858. doi: 10.1259/bjr.20170858. Epub 2018 Jul 31.
: The purpose of this study is to compare contrast-enhanced ultrasound (CEUS) to MRI for evaluating local invasion of cervical cancer.
: A total of 108 patients with cervical cancer were included in this study. All the enrolled patients were Stage IIA2-IVB according to the International Federation of Obstetrics and Gynecology and treated with volumetric modulated arc therapy. Tumour size in different dimensions was compared between MRI and CEUS. The correlation coefficients (r) between MRI and CEUS for diagnosing local invasion, parametrial extension, and invasion to vagina, uterine corpus and adjacent organs were assessed.
: Measurements by MRI and CEUS were strongly correlated in the three dimensions: left-right r = 0.84, craniocaudal r = 0.86 and anteroposterior r = 0.88. Vaginal and parametrial invasion were detected by both MRI and CEUS with moderate concordance, and invasion of uterine corpus, bladder and rectum with good concordance.
: CEUS is comparable to MRI for measuring tumour size, with good concordance for evaluating invasion of cervical cancer.
: CEUS is a less expensive non-invasive modality for assessment of tumour size and invasion of cervical cancer.
本研究旨在比较超声造影（CEUS）与磁共振成像（MRI）在评估宫颈癌局部浸润方面的效果。
本研究共纳入108例宫颈癌患者。所有入组患者根据国际妇产科联盟分期为IIA2-IVB期，并接受容积调强弧形放疗。比较MRI和CEUS测量的不同维度肿瘤大小。评估MRI和CEUS在诊断局部浸润、宫旁组织浸润以及阴道、子宫体和邻近器官浸润方面的相关系数（r）。
MRI和CEUS在三个维度上的测量结果高度相关：左右方向r = 0.84，头脚方向r = 0.86，前后方向r = 0.88。MRI和CEUS对阴道和宫旁组织浸润的检测具有中度一致性，对子宫体、膀胱和直肠浸润的检测具有良好的一致性。
CEUS在测量肿瘤大小方面与MRI相当，在评估宫颈癌浸润方面具有良好的一致性。
CEUS是一种评估宫颈癌肿瘤大小和浸润的成本较低的非侵入性方法。
