McConville E, Smith D, Bélanger E, Ivory C
1 The Ottawa Hospital, Riverside Campus, Department of Medicine, Division of Rheumatology.
2 The Ottawa Hospital, General Campus, Department of Pathology and Laboratory Medicine, Division of Anatomical Pathology.
Lupus. 2018 Sep;27(10):1732-1734. doi: 10.1177/0961203318785776. Epub 2018 Jul 20.
We present a case of scleroderma overlap syndrome with systemic lupus erythematosus (SLE) including complications of both scleroderma renal crisis and lupus nephritis. Our patient was initially diagnosed with undifferentiated connective tissue disease in 1996. A diagnosis of scleroderma was made in 2010 after she developed scleroderma renal crisis. She remained stable until 2016, when she presented with Salmonella bacteremia, renal failure, nephrotic range proteinuria and microscopic hematuria. Laboratory findings were consistent lupus with positive ds-DNA, hypocomplementemia and repeat renal biopsy showed lupus nephritis.
我们报告一例硬皮病重叠综合征合并系统性红斑狼疮（SLE）的病例，该病例同时出现了硬皮病肾危象和狼疮性肾炎两种并发症。我们的患者最初于1996年被诊断为未分化结缔组织病。2010年她发生硬皮病肾危象后被诊断为硬皮病。她的病情一直稳定，直到2016年，她出现了沙门菌血症、肾衰竭、肾病范围蛋白尿和镜下血尿。实验室检查结果与狼疮相符，双链DNA阳性、补体低下，重复肾活检显示为狼疮性肾炎。
