Li Yan, Du Yuru, Yang Juxiang, Xiu Zi, Yang Ni, Zhang Jiayu, Gao Yuan, Li Bing, Shi Haishui
Department of Chemistry.
Department of Biochemistry and Molecular Biology, College of Basic Medicine.
Neuroreport. 2018 Oct 17;29(15):1264-1268. doi: 10.1097/WNR.0000000000001102.
Depression is a highly debilitating and life-threatening mental disorder, which is accompanied by dysregulation of the peripheral and central immune system. Narirutin (NR), which has antioxidant and anti-inflammatory activities, is one of the active constituents isolated from Citrus unshiu. However, its potential antidepressant-like and anxiolytic-like effects are poorly understood. The present study was aimed to investigate whether NR confers an antidepressant-like effect in mice exposed to a chronic mild stress (CMS) model of depression. The results showed that NR treatment for 1 week significantly alleviated the depressive-like behaviours of CMS-exposed mice, as indicated by restored decreased sucrose preference and shortened floating time in the forced swimming test. Moreover, NR treatment significantly blocked the CMS-induced anxiety-like behaviors, including increased time spent in the central zone in the open field test, and shortened the latency to feeding in the novelty suppressed feeding test. Taken together, our findings suggested that NR exerted potential antidepressant-like and anxiolytic-like effects in CMS mice model of depression, which support further exploration into developing NR as a novel agent to treat depression and even other stress-related disorders.
抑郁症是一种极具致残性且危及生命的精神障碍，伴有外周和中枢免疫系统失调。橙皮苷（NR）具有抗氧化和抗炎活性，是从温州蜜柑中分离出的活性成分之一。然而，其潜在的抗抑郁样和抗焦虑样作用却鲜为人知。本研究旨在调查NR对暴露于慢性轻度应激（CMS）抑郁模型的小鼠是否具有抗抑郁样作用。结果表明，NR治疗1周可显著减轻CMS暴露小鼠的抑郁样行为，如在强迫游泳试验中恢复降低的蔗糖偏好并缩短漂浮时间所示。此外，NR治疗可显著阻断CMS诱导的焦虑样行为，包括旷场试验中在中央区域停留时间增加，以及在新奇抑制摄食试验中缩短摄食潜伏期。综上所述，我们的研究结果表明，NR在CMS抑郁小鼠模型中发挥了潜在的抗抑郁样和抗焦虑样作用，这支持进一步探索将NR开发为治疗抑郁症甚至其他应激相关疾病的新型药物。
