Ahn Geunseon, Lee Jeong-Seok, Yun Won-Soo, Shim Jin-Hyung, Lee Ui-Lyong
Research Institute, T&R Biofab Co Ltd.
Department of Mechanical Engineering, Korea Polytechnic University, Gyeonggi-do.
J Craniofac Surg. 2018 Oct;29(7):1880-1883. doi: 10.1097/SCS.0000000000004747.
Bone tissue engineering technology based on scaffold has been applied for cleft lip and palate treatment. However, clinical applications of patient-specific three-dimensional (3D) scaffolds have rarely been performed. In this study, a clinical case using patient-specific 3D-printed bioresorbable scaffold with bone marrow stromal cells collected from iliac crest in the operating room has been introduced. At 6-month after transplantation, the bone volume of the newly regenerated bone was approximately 45% of the total defect volume. Bone mineral density of the newly regenerated bone was about 75% compared to the surrounding bone. The Hounsfield unit value was higher than that of cancellous maxillary alveolar bone and lower than that of the cortical maxillary alveolar bone. Bone-marrow-derived mesenchymal stem cells-seeded 3D-printed patient-specific polycaprolactone scaffolds offer a promising alternative for alveolar cleft reconstruction and other bony defects.
基于支架的骨组织工程技术已应用于唇腭裂治疗。然而，针对患者定制的三维（3D）支架的临床应用却很少开展。在本研究中，介绍了一个临床病例，该病例使用了在手术室从髂嵴采集的骨髓基质细胞与针对患者定制的3D打印生物可吸收支架。移植后6个月，新再生骨的骨体积约占总缺损体积的45%。新再生骨的骨密度约为周围骨的75%。亨氏单位值高于上颌骨松质骨，低于上颌骨皮质骨。接种了骨髓间充质干细胞的3D打印患者定制聚己内酯支架为牙槽嵴裂修复及其他骨缺损提供了一种有前景的替代方案。
