[儿茶酚胺能系统参与大鼠戒断综合征发生发展的药理学分析]
[Pharmacological analysis of the participation of the catecholaminergic system in the development of the abstinence syndrome in rats].
作者信息
Varkov A I
出版信息
Farmakol Toksikol. 1985 Nov-Dec;48(6):11-3.
The behavioural activity of rats in "the open field" was studied. It was revealed that rats alcoholized for 8 months do not practically differ in their behavioural indicators from the intact ones. After the discontinuation of alcohol marked disturbances appear in their behaviour, that are arrested by apomorphine (0,1 mg/kg). In intact animals dopamine (50 mkg into the brain ventricles) induces behavioural disorders similar to those in rats during abstinence. Noradrenaline does not induce similar disorders. A conclusion is made on the dopaminergic nature of disorders in the behaviour of rats in the state of alcohol abstinence.
研究了大鼠在“旷场”中的行为活动。结果显示，经8个月酒精处理的大鼠，其行为指标与未处理的大鼠实际上并无差异。停止酒精摄入后，它们的行为出现明显紊乱，而阿扑吗啡（0.1毫克/千克）可抑制这些紊乱。在未处理的动物中，多巴胺（50微克注入脑室）会引发类似于大鼠戒酒期间出现的行为紊乱。去甲肾上腺素不会引发类似的紊乱。由此得出结论，大鼠戒酒状态下行为紊乱具有多巴胺能性质。
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