Tkachenko I I, Kagan Iu S, Kokshareva N V, Badaeva L N
Farmakol Toksikol. 1985 Nov-Dec;48(6):80-3.
It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.
已经确定，在很宽的剂量范围（3000 - 25毫克/千克）内给鸡施用四硫代焦磷酸酯会产生延迟性神经毒性作用，表现为共济失调、轻瘫和瘫痪的发展；兴奋通过外周轴突的传播速度延迟、肌神经兴奋性紊乱；髓鞘纤维变性、髓鞘局灶性颗粒状降解。鉴于化学纯的四硫代焦磷酸酯也有这种作用，所以延迟性神经毒性作用不是由工业级制剂所含杂质引起的。
