Drzhevetskaia I A, Butova O A
Farmakol Toksikol. 1985 Nov-Dec;48(6):93-6.
The authors review the effect of alcoholic intoxication of mother's body during lactation on hypothalamo-hypophyseal-adrenocortical function (HHACF) of the offspring both at rest and during performance of muscle exercise of medium duration. During lactation, alcoholic intoxication disturbs the normal development of HHACF), with the disturbances being persistent and aggravated with age. The offspring of rats exposed to alcoholic intoxication responded to muscle exercise by a significant lowering of all the parameters under study. Of paramount importance are two concepts derived from the studies described. First, it is clearly seen that abnormalities are experienced both by the adrenal cortex and the central component of HHACF--the hypothalamic control of the corticotropic function of the hypophysis. Second, the data obtained enrich the concepts about the adverse action of alcohol on the offspring (alcohol intake by lactating mothers).
作者回顾了哺乳期母亲身体酒精中毒对后代下丘脑 - 垂体 - 肾上腺皮质功能（HHACF）在静息状态以及进行中等时长肌肉运动时的影响。在哺乳期，酒精中毒会干扰HHACF的正常发育，这种干扰会持续存在且随年龄增长而加剧。暴露于酒精中毒的大鼠后代在进行肌肉运动时，所研究的所有参数均显著降低。从所描述的研究中得出的两个概念至关重要。首先，很明显肾上腺皮质和HHACF的中枢部分——下丘脑对垂体促肾上腺皮质激素功能的控制——都出现了异常。其次，所获得的数据丰富了关于酒精对后代（哺乳期母亲饮酒）不良作用的概念。
