Drzhevetskaia I A, Butova O A
Farmakol Toksikol. 1984 May-Jun;47(3):84-7.
Administration of alcohol (20% ethanol) to female rats for the whole pregnancy leads to activation in the progeny of the hypothalamus-pituitary-adrenocortical system (GPACS). This manifests in an increase in corticoliberin production by neurosecretory cells of the hypothalamus, secretion of ACTH by the pituitary, and high production of corticosteroids by the adrenals. Activation of the GPACS which is demonstrable in fetuses and in young rats aged 1-3 days and 1 and 3 months is replaced by this system inhibition by the age of 6 months. Therefore, alcoholic intoxication of the mother's body has a toxic effect on all the components of the GPACS (production of corticoliberin and ACTH, corticosteroid function of the adrenals).
在整个孕期给雌性大鼠投喂酒精（20%乙醇）会导致其后代的下丘脑-垂体-肾上腺皮质系统（GPACS）被激活。这表现为下丘脑神经分泌细胞促肾上腺皮质激素释放因子分泌增加、垂体促肾上腺皮质激素（ACTH）分泌以及肾上腺皮质类固醇分泌增多。在胎儿以及1 - 3日龄、1个月和3个月大的幼鼠中可证实的GPACS激活，到6个月大时被该系统抑制所取代。因此，母体的酒精中毒对GPACS的所有组成部分（促肾上腺皮质激素释放因子和ACTH的分泌、肾上腺的皮质类固醇功能）都有毒性作用。
