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[脑多巴胺受体在经母乳摄入酒精的大鼠子代下丘脑-垂体-肾上腺皮质系统功能改变中的作用]

[The participation of the brain dopamine receptors in the functional alteration of the hypothalamo-hypophyseal-adrenal cortex system in rat progeny that received alcohol with the maternal milk].

作者信息

Drzhevetskaia I A, Butova O A

出版信息

Eksp Klin Farmakol. 1994 Sep-Oct;57(5):40-3.

PMID:7696905
Abstract

The rat experiments have shown that cerucal-induced blockade of dopamine receptors in the brain normalizes hypothalamo-hypophyseo-adrenocortical parameters in the early postnatal period in newborn rats alcoholized during lactation, as well as reduces the functional activity of the links in this system in the formation of sexual maturity and early puberty. It is suggested that dopamine might play a significant role in the mechanism of action of alcohol through its receptors on the rat offsprings' hypothalamo_hypophyseo-adrenocortical system.

摘要

大鼠实验表明,在哺乳期经酒精处理的新生大鼠出生后早期,西卢卡(cerucal)诱导的脑内多巴胺受体阻断可使下丘脑 - 垂体 - 肾上腺皮质参数恢复正常,同时在性成熟和青春期早期形成过程中降低该系统各环节的功能活性。有人认为,多巴胺可能通过其在大鼠后代下丘脑 - 垂体 - 肾上腺皮质系统上的受体,在酒精作用机制中发挥重要作用。

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