Department of Ophthalmology, Seattle Children's Hospital, Seattle, Washington.
Department of Ophthalmology, University of Washington, Seattle, Washington.
Retin Cases Brief Rep. 2021 May 1;15(3):310-313. doi: 10.1097/ICB.0000000000000793.
Few cases of exudative retinal detachments have been reported in the literature after laser treatment for retinopathy of prematurity, and none of the cases include optical coherence tomography images.
Case report.
A 469-g birth weight, 25-week gestational age baby girl at 35-week postmenstrual age received a retinal laser (1,724 spots in the right eye and 1,287 spots in the left eye) for bilateral Stage 3 Zone II plus disease retinopathy of prematurity. The patient developed a large macular exudative retinal detachment seen in the right eye at the first follow-up, 5 days after the laser. Serial handheld optical coherence tomography demonstrated resolution of retinal detachment and intraretinal fluid over the course of 4 weeks with only topical tobramycin/dexamethasone ophthalmic ointment 3 to 4 times daily for 2 weeks. The patient was left with a residual subretinal scar and outer retinal loss on optical coherence tomography, with a later appearance of a dragged macula on funduscopic examination noted at 52-week postmenstrual age. It is unclear whether systemic steroid therapy, intravitreal bevacizumab, or surgery would hasten resolution of exudative retinal detachment after the retinopathy of prematurity laser and avoid photoreceptor damage seen on optical coherence tomography in this case.
This case suggests that post-retinopathy of prematurity laser exudative retinal detachments can resolve without aggressive intervention, but may cause permanent retinal sequelae.
早产儿视网膜病变激光治疗后发生渗出性视网膜脱离的病例在文献中鲜有报道,且均无光学相干断层扫描图像。
病例报告。
一名体重 469 克、胎龄 25 周的女婴,于矫正胎龄 35 周时因双眼 3 区 2 期+疾病行视网膜激光光凝治疗(右眼 1724 个光斑,左眼 1287 个光斑)。激光治疗后 5 天,即首次随访时右眼出现大的黄斑部渗出性视网膜脱离。连续行手持光学相干断层扫描检查显示,视网膜脱离和视网膜内液在 4 周内逐渐消退,仅局部使用妥布霉素/地塞米松眼药膏,每日 3 至 4 次,持续 2 周。光学相干断层扫描显示患者仍有视网膜下瘢痕和外层视网膜丢失,矫正胎龄 52 周时眼底检查发现黄斑牵拉。早产儿视网膜病变激光治疗后发生渗出性视网膜脱离时,是否应积极行全身激素治疗、玻璃体内注射贝伐单抗或手术以促进视网膜脱离的吸收,避免本例中观察到的光学相干断层扫描上的光感受器损伤,目前尚不清楚。
本病例提示早产儿视网膜病变激光光凝后发生的渗出性视网膜脱离可自行消退而无需积极干预,但可能导致永久性视网膜病变。