Marin S, Campins L, Miarons M, Pérez-Cordón L, Reina-Aguilar C, Solsona M
Consorci Sanitari del Maresme, Pharmacy, Mataro, Spain.
Consorci Sanitari del Maresme, Intensive Care Unit, Mataro, Spain.
J Clin Pharm Ther. 2018 Dec;43(6):921-924. doi: 10.1111/jcpt.12751. Epub 2018 Jul 21.
Beta-lactam antibiotic (BLA) therapy is frequently needed to treat infective endocarditis (IE). Hypersensitive reactions to BLA restrict BLA therapy in allergic patients. In the current case, we aim to describe the utility of desensitization (DS) in this context. Although the evidence is limited, DS is recommended.
This case report deals with a 79-year-old woman with a clinical suspicion of allergy to BLA and a methicillin-sensitive Staphylococcus aureus (MSSA) IE. A cloxacillin DS protocol was developed to enable treatment with cloxacillin.
Alternative antibiotic treatments may be less effective or not available in MSSA IE. In this case report, DS allowed optimal cloxacillin treatment.
治疗感染性心内膜炎（IE）时常需使用β-内酰胺类抗生素（BLA）。对BLA的超敏反应限制了其在过敏患者中的应用。在本病例中，我们旨在描述脱敏（DS）在此情况下的效用。尽管证据有限，但仍推荐使用DS。
本病例报告涉及一名79岁女性，临床怀疑对BLA过敏且患有甲氧西林敏感金黄色葡萄球菌（MSSA）IE。制定了氯唑西林DS方案以实现用氯唑西林进行治疗。
在MSSA IE中，替代抗生素治疗可能效果较差或无法获得。在本病例报告中，DS实现了氯唑西林的最佳治疗。
