Apellaniz G, Valdés M, Pérez R, Martín-Luengo F, García A, Soria F, Gómez J
Cátedra de Medicina Facultad de Medicina, Universidad de Murcia.
Enferm Infecc Microbiol Clin. 1991 Apr;9(4):208-10.
Thirty-three rabbits, (12 in the control group and 21 treated, 5 with teicoplanin, vancomycin and cloxacillin-gentamycin and 6 with cloxacillin alone) with methicillin-sensitive Staphylococcus aureus (MSSA) experimentally induced endocarditis were studied to evaluate the efficacy of teicoplanin and its comparison with cloxacillin, vancomycin and cloxacillin-gentamycin. The rabbits were treated during three days. Mortality, blood cultures at 48 and 72 hours and the number of colonies forming units per gram of vegetation were then evaluated. There was statistically significantly differences between the control group and the 4 treated groups in respect of mortality (p less than 0.001), and blood culture's negativity at 48 and 72 hours (p less than 0.001), but not among the various groups of treatments. The CFU number of the vegetations were also significantly different between control and treatment groups (p less than 0.001). Cloxacillin and the combination cloxacillin-gentamycin lowered the CFU number more than teicoplanin and vancomycin (p less than 0.005). These results, allowed us to conclude than teicoplanin may be used as an alternative of standard treatments in infective endocarditis due to MSSA.
对33只经实验诱导产生耐甲氧西林金黄色葡萄球菌（MSSA）性心内膜炎的兔子（12只作为对照组，21只接受治疗，其中5只用替考拉宁、万古霉素和氯唑西林-庆大霉素治疗，6只仅用氯唑西林治疗）进行研究，以评估替考拉宁的疗效及其与氯唑西林、万古霉素和氯唑西林-庆大霉素的比较。兔子接受了三天的治疗。然后评估死亡率、48小时和72小时的血培养结果以及每克赘生物形成菌落单位的数量。在死亡率（p<0.001）以及48小时和72小时血培养转阴率（p<0.001）方面，对照组与4个治疗组之间存在统计学显著差异，但在不同治疗组之间不存在差异。对照组和治疗组之间赘生物的菌落形成单位数量也存在显著差异（p<0.001）。氯唑西林和氯唑西林-庆大霉素联合用药比替考拉宁和万古霉素更能降低菌落形成单位数量（p<0.005）。这些结果使我们得出结论，替考拉宁可作为MSSA所致感染性心内膜炎标准治疗的替代药物。
