Wang Lai, Luo Gan, Zhang Long-Fei, Geng Hui-Xia
Institute of Nerve Injury and Recovery, College of Life Science, Henan University, Kaifeng 475004, Henan Province, PR China.
Institute of Chronic Disease Risks Assessment, School of Nursing and Health Sciences, Henan University, Kaifeng, 475004, Henan Province, PR China.
Prostaglandins Other Lipid Mediat. 2018 Sep;138:9-14. doi: 10.1016/j.prostaglandins.2018.07.002. Epub 2018 Jul 18.
Eicosatrienoic acids (EETs) are a class of intermediates produced during arachidonic acid metabolism mediated by cytochrome P450 epoxygenases that exert multiple physiological effects on the nervous system. EETs promote three metabolic processes, including esterification, hydrolysis and degradation or extension. EETs are hydrolyzed by soluble epoxide hydrolase (sEH) to form corresponding diols, thereby reducing their biological activity. Strategies regulating sEH expression or activity affect EET hydrolysis and alter relative cell concentrations, thus influencing EET function. This article summarizes the metabolic pathway of eicosatrienoic acid in organisms and highlights its neuroprotective effects on the central nervous system, which include regulating neuronal excitability, increasing cerebral blood flow, inhibiting neuronal apoptosis, reducing neuroinflammation, mitigating brain injury and promoting recovery of neurological function in subjects with nervous system diseases.
二十碳三烯酸（EETs）是一类在细胞色素P450环氧化酶介导的花生四烯酸代谢过程中产生的中间体，对神经系统具有多种生理作用。EETs促进三种代谢过程，包括酯化、水解以及降解或延长。EETs被可溶性环氧化物水解酶（sEH）水解形成相应的二醇，从而降低其生物活性。调节sEH表达或活性的策略会影响EET水解并改变相对细胞浓度，进而影响EET功能。本文总结了二十碳三烯酸在生物体内的代谢途径，并着重介绍了其对中枢神经系统的神经保护作用，包括调节神经元兴奋性、增加脑血流量、抑制神经元凋亡、减轻神经炎症、减轻脑损伤以及促进神经系统疾病患者神经功能的恢复。
