Trafficking of lysosomal enzymes in normal and disease states.
作者信息
Kornfeld S
出版信息
J Clin Invest. 1986 Jan;77(1):1-6. doi: 10.1172/JCI112262.
Abstract
摘要
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Trafficking of lysosomal enzymes in normal and disease states.正常和疾病状态下溶酶体酶的运输
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Cysteine34 of the cytoplasmic tail of the cation-dependent mannose 6-phosphate receptor is reversibly palmitoylated and required for normal trafficking and lysosomal enzyme sorting.阳离子依赖性甘露糖 6-磷酸受体胞质尾的半胱氨酸 34 可发生可逆性棕榈酰化，是正常运输和溶酶体酶分选所必需的。
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本文引用的文献
1
Transport and processing of lysosomal enzymes by smooth muscle cells and endothelial cells.溶酶体酶在平滑肌细胞和内皮细胞中的运输与加工
Exp Cell Res. 1981 May;133(1):23-30. doi: 10.1016/0014-4827(81)90352-9.
2
Maturation of alpha-L-iduronidase in cultured human fibroblasts.α-L-艾杜糖醛酸酶在培养的人成纤维细胞中的成熟过程。
J Biol Chem. 1981 Mar 25;256(6):3044-8.
3
Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling.氯喹通过损害受体再循环抑制溶酶体酶的胞饮作用并增强溶酶体酶的分泌。
J Cell Biol. 1980 Jun;85(3):839-52. doi: 10.1083/jcb.85.3.839.
4
Assay and purification of a solubilized membrane receptor that binds the lysosomal enzyme alpha-L-iduronidase.一种可溶膜受体的检测与纯化，该受体可结合溶酶体酶α-L-艾杜糖苷酶。
Arch Biochem Biophys. 1982 Apr 1;214(2):681-7. doi: 10.1016/0003-9861(82)90074-1.
5
Biosynthesis of lysosomal hydrolases: their synthesis in bound polysomes and the role of co- and post-translational processing in determining their subcellular distribution.溶酶体水解酶的生物合成：它们在附着核糖体中的合成以及共翻译和翻译后加工在决定其亚细胞分布中的作用。
J Cell Biol. 1982 Apr;93(1):135-43. doi: 10.1083/jcb.93.1.135.
6
Cloning of a cDNA complementary to rat preputial gland beta-glucuronidase mRNA.与大鼠包皮腺β-葡萄糖醛酸酶mRNA互补的cDNA的克隆
Biochem Biophys Res Commun. 1982 Feb 26;104(4):1271-8. doi: 10.1016/0006-291x(82)91387-0.
7
Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight.成纤维细胞中溶酶体酶的生物合成。以高分子量前体形式合成。
J Biol Chem. 1980 May 25;255(10):4937-45.
8
Mucolipidosis III is genetically heterogeneous.黏脂贮积症III型在遗传上具有异质性。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7420-4. doi: 10.1073/pnas.79.23.7420.
9
Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease.β-己糖胺酶在无细胞翻译体系及完整成纤维细胞中的合成：一种罕见形式的泰-萨克斯病中的不溶性前体α链
Proc Natl Acad Sci U S A. 1982 Oct;79(20):6360-4. doi: 10.1073/pnas.79.20.6360.
10
Biosynthesis and transport of cathepsin D in cultured human fibroblasts.组织蛋白酶D在培养的人成纤维细胞中的生物合成与运输
J Cell Biol. 1983 Jul;97(1):1-5. doi: 10.1083/jcb.97.1.1.
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