Research Institute of Surface Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Research Institute of Surface Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:153-162. doi: 10.1016/j.msec.2018.05.036. Epub 2018 May 16.
Fabrication of titanium (Ti)-based biomedical implants with appropriate topography as well as capacity for drug delivery is highly pursued in the field of orthopedic and dental implants. In this study, a biomimetic mesoporous coating imbedded with strontium (MPs-Sr) is prepared by the high current anodization (HCA) and hydrothermal treatment (HT). This coating provides a more stable mechanical performance than the conventional nanotube arrays. The Sr loading is regulated by the HT reaction time and the Sr is released in a controllable manner from the MPs-Sr surface. The hydrophilic performance of MPs-Sr are significantly improved. Furthermore, it is showed that the attachment and spreading of preosteoblast MC3T3-E1 cells are significantly up-regulated by the nanoscale topology of MPs and the doped Sr. The improved collagen secretion and matrix mineralization levels of cells are closely related with the Sr release. The excellent osteogenic properties of MPs-Sr samples highlight their promising potential for use in clinical application.
在骨科和牙科植入物领域，人们非常追求制造具有适当拓扑结构和药物输送能力的钛（Ti）基生物医学植入物。在这项研究中，通过高电流阳极氧化（HCA）和水热处理（HT）制备了嵌入锶（MPs-Sr）的仿生介孔涂层。与传统的纳米管阵列相比，这种涂层提供了更稳定的机械性能。Sr 的负载量通过 HT 反应时间来调节，Sr 可以从 MPs-Sr 表面以可控的方式释放。MPs-Sr 的亲水性能得到了显著改善。此外，研究表明 MPs 的纳米级拓扑结构和掺杂的 Sr 显著促进了前成骨细胞 MC3T3-E1 细胞的附着和扩散。细胞胶原分泌和基质矿化水平的提高与 Sr 的释放密切相关。MPs-Sr 样品的优异成骨性能突出了其在临床应用中的广阔前景。
