Glaser R, Kiecolt-Glaser J K, Speicher C E, Holliday J E
J Behav Med. 1985 Sep;8(3):249-60. doi: 10.1007/BF00870312.
This study used a prospective design to examine the influence of examination stress and loneliness on herpesvirus latency as measured by changes in antibody levels to three herpesviruses, Epstein-Barr virus (EBV), Herpes simplex type I (HSV-1), and cytomegalovirus (CMV). Three blood samples were obtained from 49 first-year medical students, with the first sample drawn 1 month before final examinations, the second on the first day of final examinations, and the third during the first week after their return from summer vacation. A median split on the UCLA Loneliness Scale divided subjects into high- and low-scoring loneliness groups. There were significant changes in the antibody titers to all three herpesviruses across the sample points, with the lowest levels found in the third (low stress) sample. High-loneliness subjects had significantly higher EBV antibody titers than low-loneliness subjects. These data suggest that stress-related immunosuppression can significantly modulate herpesvirus latency.
本研究采用前瞻性设计，通过检测针对三种疱疹病毒（爱泼斯坦-巴尔病毒（EBV）、单纯疱疹病毒I型（HSV-1）和巨细胞病毒（CMV））的抗体水平变化，来研究考试压力和孤独感对疱疹病毒潜伏的影响。从49名一年级医学生身上采集了三份血样，第一份样本在期末考试前1个月采集，第二份在期末考试第一天采集，第三份在他们暑假归来后的第一周采集。根据加州大学洛杉矶分校孤独量表的中位数划分，将受试者分为高孤独得分组和低孤独得分组。在所有三个样本点，针对这三种疱疹病毒的抗体滴度均有显著变化，其中在第三个（低压力）样本中发现的水平最低。高孤独感受试者的EBV抗体滴度显著高于低孤独感受试者。这些数据表明，与压力相关的免疫抑制可显著调节疱疹病毒的潜伏。
